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Primary systemic anaplastic large cell lymphoma in a single Korean institution: Clinical characteristics and treatment outcome

Cited 4 time in Web of Science Cited 8 time in Scopus
Authors
Park, Sook Ryun; Baek, Ji Yeon; Kim, Dong-Wan; Im, Seock-Ah; Kim, Tae-You; Bang, Yung-Jue; Kim, Noe Kyeong; Jeon, Yoon Kyung; Kim, Chul Woo; Heo, Dae Seog
Issue Date
2006-08
Publisher
Korean Academy of Medical Science
Citation
Journal of Korean Medical Science, Vol.21 No.4, pp.633-638
Keywords
lymphomalarge cellKi-1CD30-positive anaplastic large-cell lymphomaanaplastic lymphoma kinasedrug therapy
Abstract
Despite advances in the characterization of anaplastic large cell lymphoma (ALCL), little data is available on Asian patients. We report here upon single Korean institution's experience regarding the clinical characteristics and outcomes of ALCL. We performed a retrospective study of 32 adults with ALCL. Most of the patients received anthracycline-based chemotherapy. Ann Arbor stage III-IV, B symptoms, high-intermediate/high International Prognostic Index (IPI), and extranodal disease at diagnosis were present in 56%, 44%, 41%, and 63%, respectively. Compared with Western studies, the male/female ratio (4.3) was markedly higher and skin (9%) and bone involvement (9%) were less frequent. The staining results for anaplastic lymphoma kinase were positive in 6 (33%) of 18 cases available. The complete response (CR) rate was 62% (95% CI, 44-80%). With a median follow-up of 51.0 months, 5 yr overall survival was 40 +/- 11%. The 3 yr relapse-free survival for the 18 patients who achieved CR was 74 +/- 12%. Age, performance status, lactate dehydrogenase, extranodal disease sites number, and IPI were correlated with treatment response and survival. Our data suggest that Korean ALCL patients appear to have a higher male/female ratio, less frequent skin/bone involvement, and lower CR rate compared with those of Western studies.
ISSN
1011-8934
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16891805

http://hdl.handle.net/10371/47161
DOI
https://doi.org/10.3346/jkms.2006.21.4.633
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College of Medicine/School of Medicine (의과대학/대학원)Cancer Research Institute (암연구소)Journal Papers (저널논문_암연구소)
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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