S-Space College of Dentistry/School of Dentistry (치과대학/치의학대학원) Dept. of Dentistry (치의학과) Journal Papers (저널논문_치의학과)
다공질 calcium polyphosphate의 생분해성에 관한 연구
Biodegradability of porous Calcium Polyphosphate
- 양승민; 이영규; 한은영; 김석영; 계승범; 이승진; 이용무; 구영; 한수부; 정종평; 최상묵; 류인철
- Issue Date
- 대한치주과학회지, 31:555-564, 2001
- The purpose of this study is to evaluate the bioresorbability of Calcium Polyphosphate added with Na2O and chitosan. Though calcium phosphate ceramics meet some of the needs for bone replacement, they have some limitation of unresorbability and fibrous encapsulation without direct bone apposition during bone remodelling. To solve these problem, we developed a new ceramic, calcium polyphosphate(CPP), and report the biologic response to CPP in extraction sites of beagle dog. Porous CPP granules were prepared by condensation of anhydrous $Ca(H_2PO_4)_2$ to form non-crystalline Ca(PO3)2. CPP granules added with Na2O and chitosan were implanted in extraction sockets and histologic observation were performed at 12 weeks later. Histologic observation at 12 weeks revealed that CPP matrix were mingled with and directly apposed to new bone without any intervention of fibrous connective tissue. CPP granules added with chitosan were well adatped without any adverse tissue reaction and resorbed slowly and spontaneously. CPP granules added with Na2O and chitosan show multinucleated giant cells and osteoblast-like cells around grafted material and newly formed bone. This result revealed that CPP, regardless of its additive component, had a high affinity for bone and had been resorbed slowly. From this results, it was suggested that CPP is promising ceramic as a bone substitute and addition of Na2O and chitosan help biodegradation. In further study , it will be determined which concentration of Na2O help biodegradation and the other additive components increase the degradation rate.