Browse

A Field-Effect-Transistor Sensor Based on Polypyrrole Nanotubes Coupled with Heparin for Thrombin Detection

Cited 10 time in Web of Science Cited 10 time in Scopus
Authors
Yoon, Hyeonseok; Jang, Jyongsik
Issue Date
2008
Publisher
Taylor & Francis
Citation
Mol. Cryst. Liq. Cryst., 491, 21–31
Keywords
biosensensorsfield-effect transistorsheparinpolypyrrolethrombin
Abstract
Carboxylated polypyrrole (CPPy) nanotubes were fabricated by the chemical
copolymerization of pyrrole and pyrrole-3-carboxylic acid (P3CA) using cylindrical
micelle templates. Importantly, the chemical functionality of CPPy nanotubes was
determined by the input amount of P3CA and their redox property was also
retained without degradation. A field-effect-transistor (FET) sensor platform
was constructed using liquid-ion gating. CPPy nanotubes were anchored on an
amine-functionalized Au interdigitated microelectrode substrate to achieve high
quality contact at the polymer=metal interface. Subsequently, heparin was covalently
conjugated with the CPPy nanotubes via a diamino linker. The FET sensor
based on heparin-conjugated CPPy nanotubes showed specific and fast response
upon exposure to thrombin protein.
ISSN
1542-1406
Language
English
URI
http://hdl.handle.net/10371/48985
DOI
https://doi.org/10.1080/15421400802328725
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Journal Papers (저널논문_화학생물공학부)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse