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Regulation of K+ channels may enhance wound healing in the skin

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Authors
Kang, Dawon; Choi, Tae Hyun; Han, Kihwan; Son, Daegu; Kim, Jun Hyung; Kim, Sang-Hyon; Park, Jungbin
Issue Date
2008-08-29
Publisher
Elsevier
Citation
Med Hypotheses 2008;71:927-929
Description
Authors' final draft
Abstract
In the process of promoting wound healing, epidermal growth factor (EGF) activates protein kinase C, protein tyrosine kinase and ERK MAPK (mitogen-activated protein kinase). The activation of these mediators in signal pathways can regulate the operation of K+ channels. In addition, the K+ channel is involved with cell migration and proliferation, both of which are requisite for wound healing. Recent studies, although not conducted on skin wounds, have found that the K+ channel is associated with wound healing and that wound healing can be promoted by regulating the K+ channels. Therefore, the authors hypothesize that healing of skin wounds could be promoted by regulating K+ channel distribution in skin keratinocytes or fibroblasts. We plan to conduct a study of the promotion of skin wound healing using K+ channel regulators.
ISSN
0306-9877 (print)
1532-2777 (online)
Language
English
URI
http://hdl.handle.net/10371/5325
DOI
https://doi.org/10.1016/j.mehy.2008.05.038

https://doi.org/10.1016/j.mehy.2008.05.038
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College of Medicine/School of Medicine (의과대학/대학원)Plastic Surgery (성형외과학전공)Journal Papers (저널논문_성형외과학전공)
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