Detection of Human Papillomavirus(HPV) DNA in Children's Genital and Respiratory Tract Papilloma and in Birth Canals of Their Mothers

Abstract

In order to study the epidemiologic relationship between children's papillomaviral disease and papillomaviral infection of mothers, five anogenital warts and seven laryngeal papilloma in children were analyzed by polymerase chain reaction to detect HPV DNA HPV type 6 was found in 8 cases and HPV type 11 in 7 cases. Both types were found in 3 cases. From these results, anogenital warts and laryngeal papilloma in children are found to be pure viral diseases caused by HPV type 6 and 11. Nine cases of DNA extracted from cervical swabs from mothers of children with condyloma or laryngeal papilloma, were examined to identify possible latent infection of HPV. Among 9 cases, HPV DNA was found in two cases. These results suggest that inapparent infection of HPV type 6, 11 in the birth canal may contribute to the development of these viral diseases in their offspring aside from sexual abuse.