An Experimental Study on Automatic Control of Mean Arterial Pressure in Hypertensive Rabbits by means of Adaptive Control System using Sodium Nitroprusside Dihydrate

Abstract

There are clinical conditions when rapid control of hypertension is needed, such as malignant hypertension, hypertensive left ventricular failure and encephalopathy, and perioperative management of hypertensive patients requiring emergency operation. The rapid reduction of blood pressure can be achieved with closed-loop type blood pressure controllers safely and rapidly. Among them, pole assignment self-tuning control algorithm, a newly adopted adaptive control algorithm using sodium nitroprusside dihydrate, showed excellent results in our experiment with hypertensive rabbits. Convergence time to a set point was less than 630 seconds and standard deviation of maintained blood pressure was within 3.9 mmHg.