In vitro and In vivo Effects of Praziquantel on Sparganum
스파르가눔에 대한 프라지콴텔의 살충효과 : 시험관내 및 실험감염 마우스 체내에서의 관찰

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Lee, Soon-Hyung; Chai, Jong-Yil; Sohn, Woon-Mok; Hong, Sung-Jong; Lee, Keun-Chan
Issue Date
Seoul National University College of Medicine
Seoul J Med 1986;27(2):135-142
SparganumPreziquentelSparganocidal activity
An experimental study was performed to observe in vitro and in vivo effects of
praziquantel on sparganum, For in vitro study, various concentrations of praziquantel solution
(0,01, 0,1, 1, 10, 100 p g/ml) were prepared and spargana collected from the snake were
incubated, For in vivo study, total 18 mice were fed each with 5-10 scolices of spargana,
treated after 2-8 weeks with 100 mg/kg/day praziquantel for 1-5 days, and sacrificed 1 week
Following results were obtained:
L After in vitro incubation with higher than 0.1 p g/ml praziquantel the spargana expanded
laterally, lost their motility and finally became immobilized, Praziquantel revealed greater
effects on the neck portion of spargana, which was severely disintegrated into fragments,
2. In in vivo study, the worm recovery rates from control and praziquantel-treated mice
were not different each other, to be in the range of 60-80%, and all worms recovered were
alive, This result represented a failure in the treatment of sparganosis of mice,
3. However, in mice treated with praziquantel, a histological observation sometimes revealed
a significant degree of destructive changes in the tegument of worms as well as invasion of
host cells such as eosinophils and histiocytes.
The results showed that praziquantel was highly effective in killing spargana in vitro,
it did not show strong sparganocidal activity in vivo of mice by the drug regimen applied,
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 27 No.2 (1986)
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