SHERP

Circulating Immune Complexes in Korean Hemorrhagic Fever -Hemorrhagic Fever with Renal Syndrome-
한국형출혈열에서의 혈중 면역복합체에 관한 연구

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Authors
Park, Jung Sik; Kim, Suhnggwon; Lee, Jung Sang; Lee, Munho
Issue Date
1986-06
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med 1986;27(2):143-153
Keywords
Korean hemorrhagic fever; Circulating immune complex; Platelet aggregation test; Clq-gel diffusion test; Polyethylene glycol precipitation test
Abstract
To clarify the presence and the role of immune complexes in the pathogenesis
of Korean hemorrhagic fever. circulating immune complexes were measured by platelet
aggregation test, C1q-gel diffusion test, and polyethylene glycol precipitation test in the blood
from the 24 patients during the early phase of Korean hemorrhagic fever. Serum complement
and immunoglobulins were also measured. In all patients, circulating immune complexes were
detected by one or more test. Detection rate of circulating immune complexes was 100% in
the early phase and gradually decreased in the late phase, During the early phase of Korean
hemorrhagic fever, the level of C3 decreased significantly and the level of immunogIubulin M
increased from the fifth day of illness. Positive rate of circulating immune complexes were
significantly correlated to decreased C3 level and severity of disease, It was concluded that
circulating immune complexes play important roles in the pathogenesis of Korean hemorrhagic
fever.
ISSN
0583-6802
Language
English
URI
http://hdl.handle.net/10371/5503
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 27 No.2 (1986)
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