SHERP

A Study of Interhemispheric Diaschisis:Reduction of Cerebral Blood Flow in Both Hemispheres Following Unilateral Middle Cerebral Artery Occlusion in Cats
대뇌반구간 기능해리 현상에 관한 연구

Cited 0 time in webofscience Cited 0 time in scopus
Authors
Han, Dae Hee; Jung, Hee-Won; Lee, Sun Ho; Min, Byoung Goo; Sim, Bo Sung
Issue Date
1986-06
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med 1986;27(2):173-180
Keywords
Interhemispheric diaschisis; Regional cerebral blood flow; Cerebral infarction; Hydrogen clearance method
Abstract
To demonstrate the effect of interhemispheric diaschisis in acute unilateral cerebral
infarction, the changes of regional cerebral blood flow (rCBF) following experimental
occlusion of one middle cerebral artery(MCA) for up to 16 hours were investigated in an
unanesthetized cat model using the technique of transorbital snare ligature implanted in the
intact cranium. rCBF of both MCA territories and both marginal zones were measured simultaneously
by the hydrogen clearance technique. 25 cats were divided into 2 groups according
to the size of infarct; Group A, infarct larger than 10% of ipsilateral coronal sectional surface of
hemisphere and Group B, smaller than 10%. DUring the initial stage of ischemia, significant
decrease in rCBF of the contralateral hemisphere was observed in both groups, however, in
Group A, rCBF gradually increased toward preocclusion level. In Group B, rCBF decreased
further and remained low till the 16th hour after occlusion. These results suggested that mild
ischemic Group B would take advantage of interhemispheric diaschisis during the late phase of
infarct development as well as the substantial collateral flow from the surrounding anterior and
posterior cerebral artery territories.
ISSN
0583-6802
Language
English
URI
http://hdl.handle.net/10371/5506
Files in This Item:
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 27 No.2 (1986)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse