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Leukocyte Adherence Inhibition in Cancer Patients and the Repeated Tube LAI Assay
백혈구접착억제의 종양항원 특이성 및 반복백혈구접학억제 검사에 관한 연구

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Authors
Seo, Jeong Kee; Ko, Kwang Wook
Issue Date
1989-03
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med 1989;30(1):15-24
Keywords
Leukocyte adherence inhibitionHuman cancerthe repeated tube LA! assay
Abstract
The tube Leukocyte Adherence Inhibition (LA!) assays were performed to study
immunological reactivity of patients with a variety of tumors (lung cancer, cervix cancer,
stomach cancer and hepatoma). The result showed that leukocytes from cancer patients
reacted only to the antigenic extracts of tumors of the same type and that the LAI response
was directed to an organ type specific neoantigen.
After the initial tube LAI assay with normal lung tissue, the repeated tube LAI assay was
performed with lung cancer extracts on the resultant cells adherent to the glass tube. In 8
patients with lung cencer, the changes in the number of nonadherent cells were all above
100%, while in 9 healthy control subjects they were all below 100%. NAIs (non adherence
index) of the repeated tube LAI assay were significantly higher than those of the original tube
LAI assay in patients with lung cancer (p < 0.01).
ISSN
0583-6802
Language
English
URI
http://hdl.handle.net/10371/5530
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 30 No.1 (1989)
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