Multiple Enchondromatosis (Oilier's Disease)

Abstract

Enchondromatosis is a rare disease which accounts of 0.46"'" of all bone tumors. This report deals with pathologic analysis of 3 cases which were tudied at Department of Pathology for the last 5 years, 1983~ 1988. There were two females aged 19 years and 32 years and one 17 -year-old male. Family history was negative in all cases. Hand bones were most commonly involved. One of three cases had unilarteral distribution. Clinically they presented with painless mass with or without deformity. Radiologically multiple non-ossifying expansile radiolucent lesions were characteristic. Histologically. they were mildly or moderately cellular cartilaginous masses multilobulated by fibrovascular septa. Occasionally, in the highly cellular areas, there were foci of nuclear pleomorphism. occasional binucleated cells and bizarre nuclei. In one case mosaic ring calcifications were noted. There was no evidence of malignancy in all cases.