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Amplification of the N-myc Gene in Untreated Human Neuroblastomas
Neuroblastoma 암조직에서의 N-myc 암유전자 증폭

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Authors
Jeon, Choon Ju; Ahn, Hyo Seop; Seo, Jeong-Sun
Issue Date
1989-06
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med 1989;30(2):89-95
Keywords
N-mycGene amplificationNeuroblastoma
Abstract
Gene alteration and abnormal expression of cellular oncogenes has been
implicated in the causation of various types of malignant disease. Gene amplification is
thought to be a potent device for increasinq the amount of normal oncogene product and
has been reported in a variety of human tumors. We have now examined the amplification
of a c-myc related sequence called N-myc in several neuroblastoma tissues donated by
patients of clinical stages IV and in an established tumor cell lines. Though N-myc amplification
occurred as a common event in these patients, the degree of amplification was found to
be quite different among them so that it ranged from several fold of amplification to more
than 100 fold of amplification. Considering their clinical stages, it seemed that the degree of
N-myc amplification has some correlation with the advanced stages of the disease.
ISSN
0583-6802
Language
English
URI
http://hdl.handle.net/10371/5539
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 30 No.2 (1989)
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