Biochemical Changes of Muscle Tissues in Exercise: Effect of Training and Glutamate Infusion on Lactate Metabolism
운동중 근육조직의 생화학적 변화 : 훈련과 glutamate투여가 lactate대사에 미치는 영향

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Park, Sang Chul; Tchai, Bum Suck; Kim, Jun; Choe, Myung Ae; Kim, Chang Keun; Lee, Mee Sook; Lee, Kwang Ho; Koh, Chang Soon
Issue Date
Seoul National University College of Medicine
Seoul J Med 1989;30(3):157-162
Exercise efficiencyLactate accumulationTrainingGlutamate supply
In exercise physiology, it is inevitable for the skeletal muscle tissues to generate
and accumulate lactate in the tissues, because lactate is the final oxidized product of
glycolysis in the relative anerobic condition. The resulting accumulated lactate is supposed to
be the main cause of fatigue generation in the exercising muscle tissues. To endure severe
exercise, it is known that training can modify lactate metabolism via increase of anerobic
threshold. In order to prevent the accumulation of lactate and to activate its clearance in the
exercising muscles, it was assumed that the muscle tissue should adapt itself through training
to tolerate the high dose of lactate by induction of the related enzymes. The high dose of
glutamate infusion prior to exercise would shift GPT and LDH reactions in the direction of
lactate elimination. In the present experiment, we determined the changes of enzymic activities
such as LDH, GPT and GGTP in muscle tissues of rats after one month swimming
training and lactate clearance after strenuous exerise. We compared the glutamate effect on
prolonging the survival time. From these results, it was concluded that the enzymes of lactate
metabolism are induced in the muscle tissues and lactate clearance is stimulated by training.
Moreover, the additional supply of glutamate may improve exercise efficiency via preventing
lactate accumulation in exercising muscle tissues.
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 30 No.3 (1989)
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