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Effect of Glutamate on Lactate-Induced Performance Decrease of Muscular Contraction
Glutamate의 락트산유도 근육수축 저하 방지효과

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Authors
Choe, Myoung Ae; Kim, Jun; Seoh, Sang Ah; Kim, Chang Keun; Lee, Mee Sook; Lee, Kwang Ho; Koh, Chang Soon; Park, Sang Chul
Issue Date
1989-09
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med, Vol.30 No.3, pp. 163-169
Keywords
GlutamateLactateFatigueMuscle contraction
Abstract
The accumulation of lactate in exercising muscle causes a fatigue phenomenon
with deterioration in muscle performance. In a relative anaerobic condition, it is a normal
physiological response to generate lactate for the compensation of NAD/NADH balance of
the tissues in order to continue ATP production. The alternative route of lactate metabolism
in such a state would be opened via transamination reaction to alanine through pyruvate.
Since LDH and GPT are near-equilibrium enzymes, whose kinetics are operated under the
simple mass-action law of substrates, it is possible to modulate the metabolism of lactate
through the supply of glutamate. In the present experiment, we analyzed the effect of lactate
perfusion on muscular contractility and the preventive effect of glutamate on the lactate-induced
decrease of muscle performance. The maximal twitch tension was decreased by lactate
infusion in contrast to its increase by glutamate and its rapid decrease by alanine
infusion. From these results, it can be concluded that the administration of glutamate may
improve exercise efficiency through prevention of lactate accumulation in exercising muscle
tissues.
ISSN
0582-6802
Language
English
URI
http://hdl.handle.net/10371/5554
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 30 No.3 (1989)
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