Association of Oncogenic Human Papillomaviruses(HPV 16, 18) with Cervical Intraepithelial Neoplasia and Cervical Cancer

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Lee, Hyo Pyo; Park, No Hyun; Moon, Hye Sung; Kim, Jong Hoon; Song, Yong Sang; Kang, Soon Beom
Issue Date
Seoul National University College of Medicine
Seoul J Med 1993;34(3):207-213
Human papillomavirusPCRCervical intraepithelial neoplasiaCervix cancer
The prevalence of oncogenic human papillomavirus (HPV) type 16
and 18 was investigated by polymerase chain reaction (PCR) method in cervical
scrapes omitting prior DNA extraction. Samples were obtained from 70
gynecologic inpatients with normal cervix and 160 women with cervical
neoplastic lesion ( N = 50 in cervical intraepithelial neoplasia (CIN) I, N = 50 in
CIN II, N = 30 in CIN III, N = 30 in invasive cervical cancer). Eight members were
excluded from the data due to failure of ,f3-g10bin amplification during the PCR
procedure. The HPV 16 prevalence rate was 19.1 % (13/68) in the normal
group, 38.8 % (19/49) in CIN 1,57.1 % (28/49) in CIN 11,75.9 % (22/29) in CIN
III, 88.9% (24/27) in invasive cancer. For HPV type 18, DNA positivity was 4.4 %
(3/68), 8.2 % (4/49), 12.2 % (6/49), 13.8 % (4/29), 18.5 % (5/27),
respectively. In the whole series a consistent correlation was found between HPV
positivity and severity of cervical lesion. HPV 16 was the more prevalent type and
about five times more common than HPV 18. These results suggest that HPV 16
and 18 may be strongly associated with carcinogenesis of cervical cancer. The
high risk HPV typing by direct PCR from cervical scrapes can be used as a useful
marker for the presence of neoplastic cells and also served as a simple tool in
identifying women who are at risk of developing dysplasia and cervical cancer.
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 34 No.3 (1993)
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