Publications
Detailed Information
Effects of Calcium Channel Blockers on Sodium-Free Contracture in Atrial Muscle of the Rabbit
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Eun Kyung | - |
dc.contributor.author | Han, Jin | - |
dc.contributor.author | Kim, Eui Yang | - |
dc.contributor.author | Earm, Yung E | - |
dc.date.accessioned | 2009-07-14T23:01:37Z | - |
dc.date.available | 2009-07-14T23:01:37Z | - |
dc.date.issued | 1993-09 | - |
dc.identifier.citation | Seoul J Med, Vol.34 No.3, pp. 165-172 | - |
dc.identifier.issn | 0582-6802 | - |
dc.identifier.uri | https://hdl.handle.net/10371/5577 | - |
dc.description.abstract | Effects of organic and inorganic Ca-channel blockers on Na-Ca
exchange system were investigated in the rabbit atrial muscle. Atrial muscle strips were perfused with Kr-free Tyrode solution in order to depress the sodium pump activity. Removal of external sodium(sodium being replaced by Tris) induced a contracture which reached a maximum after 1 min and effects of Ca-channel blockers on the magnitude of contracture were analysed. The results obtained were as follows: 1. In the concentrations of 30 pM, 100 pM and 300 ,uM Mn2 + increased the magnitude of Na-removal contracture, but decreased it in the concentration above 2 ,uM. Verapamil(IO-6 M) pretreatment did not alter the effect of Mn2+ on sodium-removal contracture. 2. La3+, as Mn2+, increased the magnitude of contracture in the concentrations of 30-300 pM, and decreased the contracture in higher concentrations(> 1 mM) more prominently than Mn2+ did. 3. 0-600 also increased the contracture in the concentrations of 5 x 10-8 M, 10-7 M and 5 x 10-7 M but had no effect in higher concentratlonsfl Orf - 10-5 M), On the other hand diltiazem had no dffect on the contracture in a wide range of concentrations (up to 10-4 M). From the above results, it is concluded that Mn2+, La3+ and 0600 in lower concentrations stimulate the Na-Ca exchange system, whereas, Mn2+, La3+ and 0-600 in higher concentrations depress the exchange system and that Na-Ca exchange might be regulated by Ca-channel blockers and this regulation is sensitive to the concentration of Ca-channel blockers. | - |
dc.language.iso | en | - |
dc.publisher | Seoul National University College of Medicine | - |
dc.subject | Ca-channel blockers | - |
dc.subject | Sodium-calcium exchange | - |
dc.subject | Rabbit atrial muscle | - |
dc.subject | Sodium removal contracture | - |
dc.title | Effects of Calcium Channel Blockers on Sodium-Free Contracture in Atrial Muscle of the Rabbit | - |
dc.type | SNU Journal | - |
dc.contributor.AlternativeAuthor | 최은경 | - |
dc.contributor.AlternativeAuthor | 한진 | - |
dc.contributor.AlternativeAuthor | 김의양 | - |
dc.contributor.AlternativeAuthor | 임영이 | - |
dc.citation.journaltitle | 서울 의대 잡지 | - |
dc.citation.journaltitle | 서울 의대 학술지 | - |
dc.citation.journaltitle | Seoul Journal of Medicine | - |
dc.citation.endpage | 172 | - |
dc.citation.number | 3 | - |
dc.citation.pages | 165-172 | - |
dc.citation.startpage | 165 | - |
dc.citation.volume | 34 | - |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.