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College of Medicine/School of Medicine (의과대학/대학원)
Dept. of Medicine (의학과)
The Seoul Journal of Medicine
The Seoul Journal of Medicine Vol. 34 No.2 (1993)
ReIationship of Plasma Potassium and Hydrogen Ion Concentrations in Acidosis-Induced HyperkaIemia and HyperkaIemia-Induced Acidosis
- Authors
- Issue Date
- 1993-06
- Citation
- Seoul J Med, Vol.34 No.2, pp. 75-81
- Keywords
- Metabolic acidosis ; Hyperkalemia ; Blood pH ; Compensatory respiratory alkalosis ; Rabbit
- Abstract
- The relationship between the plasma potassium concentration and
blood pH was evaluated in acidosis-induced hyperkalemia and hyperkalemiainduced
acidosis in rabbits. In the first group of animals, metabolic acidosis was
induced by an intravenous infusion of 0.1 N hydrochloric acid, and in the second
group, hyperkalemia was induced by an intravenous infusion of 20 mM potassium
chloride solution. The third group of animals was infused with both hydrochloric
acid and potassium chloride. All three groups showed metabolic acidosis, hyperkalemia,
and compensatory respiratory alkalosis. The degree of alkalosis was
most extensive in HCl infused, and least in KCl infused animals. The simultaneous
infusion of HCl and KCl induced the most extensive change in the acid-base
status, and the hydrogen and potassium ion concentrations. However the quantitative
relationship between potassium and hydrogen ion concentrations was similar
in all three groups. It is, therefore, presumed that acidosis-induced hyperkalemia
and hyperkalemia-induced acidosis involve a common mechanism.
- ISSN
- 0582-6802
- Language
- English
- Files in This Item:
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