SHERP

Comparative Study for the Differentiation of Allergic and Irritant Contact Dermatitis in Mice

Cited 0 time in webofscience Cited 0 time in scopus
Authors
Chung, Jin Ho; Kim, Kyu Han; Koh, Woo Seok; Park, Kyoung Chan
Issue Date
1993-03
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med 1993;34(1):49-54
Keywords
Allergic and irritant contact dermatitisBALB/c miceLangerhans cellsEar swellingla (+) keratinocytes
Abstract
Our study was performed to compare the differences between
allergic and irritant contact dermatitis in BALB/c mice. Allergic reaction was
induced by a sensitizing regimen of 2,4-dinitro-l-fluorobenzene (DNFB) and
irritant reaction by 10% sodium lauryl sulfate (SLS). The following differences
were noted: 1) the mice with irritant reaction showed an earlier peak of ear
swelling, 2) increasing number of Langerhans cells (LCs) in allergic reaction but
decreasing number of LCs in irritant reaction was observed at 48 hr after
challenge of DNFB or SLS, and 3) induction of Ia (+) keratinocytes was found
only in allergic reaction. It was suggested that Ia (+) keratinocytes play an active
role in the mechanism of allergic contact dermatitis.
ISSN
0582-6802
Language
English
URI
http://hdl.handle.net/10371/5592
Files in This Item:
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 34 No.1 (1993)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse