Repetitive Nerve Stimulation and Single Fiber EIectromyography Tests for Myasthenia Gravis

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Lee, Kwang-Woo; Lee, Han-Bo
Issue Date
Seoul National University College of Medicine
Seoul J Med 1993;34(1):41-48
Repetitive nerve stimulationMyasthenia gravisSinglefiber electromyography
Sometimes it is not easy to make a diagnosis of myasthenia gravis
(MG) when the ocular symptoms are the only clinical manifestations. The authors
performed this study to understand the significance or the indication of repetitive
nerve stimulation (RNS) and single fiber electromyography (SFEMG) tests in
various stages of MG. The subjects consisted of 15 ocular, 12 generalized, 4
remitted MG, and 5 other neurologic diseases which mimicked it.Positive RNS
and SFEMG results were found in 53.3%, 86.7% of ocular type, in 0.0%, 75.0%
of remitted type, in 75.0%, 91.7% of generalized type of MG and in 0.0%, 60.0%
of other neurologic disease, respectively. When we analysed the results in 15
ocular MG and in 5 non-MG groups, the RNS tests had low sensitivity (53.3%)
and high specificity (100%) as they were positive in 8 of 15 ocular MG, and
negative in all of 5 non-MG group. Whereas the SFEMG had high sensitivity (86.
7%) and low specificity (40.0%) as it was positive in 13 of 15 ocular MG, and
negative in 2 of 5 non-MG group.Therefore it would be concluded that the
SFEMG test was much more sensitive than the RNS for the diagnosis of MG, but
would not differentiate ocular MG from other neurologic diseases whose clinical
features mimicked it. On the other hand, the diagnosis of MG would be promising
by a positive RNS test as its specificity was very high.
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 34 No.1 (1993)
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