Effect of Enteral Kanamycin on Experimentally Induced Ischemic Bowel Disease in Mice

Abstract

A mouse model using temporary occlusion of superior mesenteric vessels was tested for the effect of enteral antibiotics on the prevention and treatment of ischemic bowel disease. Ischemic bowel disease created by the temporary occlusion of mesenteric vessels was morphologically quite similar to the necrotizing enterocolitis (NEC) of the newborn. Nonabsorbable Kanamycin administered enterally was shown to prevent the development of ischemic lesions, but its therapeutic effect was not established in this experiment.