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In vitro Effects of Praziquantel on Fibricola seoulensis
Fibricola seoulensis에 대한 Praziquantel의 시험관내 작용

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Authors
Lee, Soon-Hyung
Issue Date
1985-03
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med 1985;26(1):41-51
Keywords
FibricolaDiplostomatidaePraziquantelIn vitro effectsBleb formationSEM
Abstract
In vitro effects of praziquantel on Fibricola seoulensis (Trematoda: Diplostomatidae)
viability and tegumental and/or parenchymal layer changes were studied by light and
scanning electron microscopy after exposing the worms to 0.01-100 ㎍/ml drug concentrations
up to 24 hours. The metacercariae (diplostomula) were obtained from the snake, Natrix
tigrina lateralis, and adult worms from albino rats 7-9 days after experimental infection.
From the view point of worm viability, the lowest effective lethal concentration of praziquantel
was 0.1 ㎍/ml. In 1, 10 and 100 ㎍/ml concentrations rapid contraction and immediate
death of worms were observed. Severe tegumental and subtegumental changes were recognizable
by light and electron microscopy. These changes consisted of bleb formation followed by
rupture and loss of surface integrity, and deformity of body configuration. The surface destruction
was more pronounced at ventro-lateral margins of the forebody and dorsal junctional
area between fore-and hindbody. Widening of the distance oral and ventral suckers was also
a prominent feature. Tegumental spines and sensory papillae were least affected.
ISSN
0582-6802
Language
English
URI
http://hdl.handle.net/10371/5667
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 26 No.1 (1985)
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