SHERP

A Study on Thrombokinetics In Korean Hemorrhagic Fever
한국형 출혈열에 있어서 Thrombokinetics에 관한 연구

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Authors
Park, Seonyang; Kim, Byoung Kook; Lee, Jung Sang; Lee, Munho
Issue Date
1985-03
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med 1985;26(1):69-80
Keywords
Korean hemorrhagic feverPlatelet survivalMegakaryocyte
Abstract
To elucidate the cause of thrombocytopenia in Korean hemorrhagic fever,
platelet counts, ll1In-labeled allogeneic platelet survival and bone marrow changes were
assessed in the early stage in thirteen male patients with follow-up evaluation six to eight days
later. 111In-labeled allogeneic platelet survival was decreased to 111.9 ±21.9 hours in the
early stage when the mean platelet count was 54,OOO±28,OOOlmm3
, compared with 147.8±
18.2 hours in normal controls (p<O.Ol). Significant increase of the megakaryocyte number
was observed in the bone marrow of the early stage patients while the bone marrow cellularity
showed no significant changes. The megakaryocyte size revealed no significant changes. Significant
correlations were found among the platelet survival, platelet count, megakaryocyte
number and/or megakaryocyte size in the early stage of the disease. It was concluded that
thrombocytopenia in the early stage of Korean hemorrhagic fever results from increased
consumption, but not from impaired production, of the platelets.
ISSN
0582-6802
Language
English
URI
http://hdl.handle.net/10371/5671
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 26 No.1 (1985)
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