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Evidence of a Hepadna Virus Infection in Manchurian Chipmunks : 한국산 다람쥐에서의 Hepadna virus 감염
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- Authors
- Issue Date
- 1987-03
- Citation
- Seoul J Med, Vol.28 No.1, pp. 16-21
- Keywords
- Hepadna virus ; HBsAg ; Virus particle ; Manchurian chipmunk
- Abstract
- In attempting to find a new host of hepadna virus, sera of Manchurian chipmunks
(Tamias sibiricus asiaticus ) were tested for serologic markers of hepatitis B virus and virus like
particles.
Of 47 tested animals, HBsAg reactivities were found in sera of 6 animals and anti-HBs in 7
animals by radioimmunoassay. The HBsAg-positive sera were examined by electron microscopy.
Numerous spherical particles 21 nm in diameter and many spherical double-shelled
particles 41 nm in diameter, which look similar to Dane particles, were observed in all the
HBsAg-positive sera.
The amount of 41 nm particles seems to correlate with the titer of HBsAg reactivities.
Histologic examination of liver tissues from the HBsAg and particles-positive animals showed
no evidence of liver disease.
The detection of HBsAg reactivities and particles similar in appearance to the particles of
hepatitis B virus in sera of Manchurian chipmunks strongly suggests infection of a hepadna
virus in these animals.
- ISSN
- 0582-6802
- Language
- English
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