SHERP

Evidence of a Hepadna Virus Infection in Manchurian Chipmunks
한국산 다람쥐에서의 Hepadna virus 감염

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Authors
Yoo, Byung Chul; Kim, Chung Yong
Issue Date
1987-03
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med 1987;28(1):16-21
Keywords
Hepadna virusHBsAgVirus particleManchurian chipmunk
Abstract
In attempting to find a new host of hepadna virus, sera of Manchurian chipmunks
(Tamias sibiricus asiaticus ) were tested for serologic markers of hepatitis B virus and virus like
particles.
Of 47 tested animals, HBsAg reactivities were found in sera of 6 animals and anti-HBs in 7
animals by radioimmunoassay. The HBsAg-positive sera were examined by electron microscopy.
Numerous spherical particles 21 nm in diameter and many spherical double-shelled
particles 41 nm in diameter, which look similar to Dane particles, were observed in all the
HBsAg-positive sera.
The amount of 41 nm particles seems to correlate with the titer of HBsAg reactivities.
Histologic examination of liver tissues from the HBsAg and particles-positive animals showed
no evidence of liver disease.
The detection of HBsAg reactivities and particles similar in appearance to the particles of
hepatitis B virus in sera of Manchurian chipmunks strongly suggests infection of a hepadna
virus in these animals.
ISSN
0583-6802
Language
English
URI
http://hdl.handle.net/10371/5695
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 28 No.1 (1987)
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