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Amyloid-producing Odontogenic Tumour (Calcifying Epithelial Odontogenic Tumour) in the Mandible of a Bengal Tiger (Panthera tigris tigris)

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Authors
Kang, M.-S.; Park, M.-S.; Kwon, S.-W.; Ma, S.-A.; Cho, D.-Y.; Kim, Dae-Yong; Kim, Y.
Issue Date
2006-03-13
Publisher
Elsevier
Citation
J. Comp. Path, 134, 236–240
Keywords
amyloidmandibleodontogenic tumourtigertumour
Abstract
A 13-year-old male tiger (Panthera tigris tigris) had a marked mandibular swelling noticed 12 months
earlier and associated with progressive anorexia and weight loss. Radiological and post-mortem
examination revealed a mass (13!15 cm) which was firm and poorly defined, with destruction of the
adjacent bone tissue. Histologically, the mass was poorly demarcated, with infiltrative growth, and
composed of nests, cords and islands of epithelial cells with characteristic basal cell features. Also observed
were extensive squamous metaplasia, ghost cells, stellate reticulum, and fibroblastic connective tissue
stroma containing inflammatory cells. A prominent feature of this tumour consisted of abundant nodular
deposits of congophilic amyloid-like material with partial mineralization (Liesegang rings). Immunohistochemically,
the neoplastic cells and the amyloid-like material were positive for pancytokeratin and
negative for vimentin. The findings supported the diagnosis of an amyloid-producing odontogenic
tumour (APOT), also known as calcifying epithelial odontogenic tumour in man and animals.
ISSN
0021-9975
Language
English
URI
http://hdl.handle.net/10371/6104
DOI
https://doi.org/10.1016/j.jcpa.2005.09.004
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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