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EGFR gene copy number in adenocarcinoma of the lung by FISH analysis: investigation of significantly related factors on CT, FDG-PET, and histopathology

Cited 22 time in Web of Science Cited 25 time in Scopus
Authors
Park, Eun-Ah; Lee, Hyun Ju; Kim, Young Tae; Kang, Chang Hyun; Kang, Keon Wook; Jeon, Yoon Kyung; Goo, Jin Mo; Lee, Chang Hyun; Park, Chang Min
Issue Date
2008-09-30
Publisher
Elsevier
Citation
Lung Cancer 2009;64:179–186
Keywords
Adenocarcinoma/*genetics/*radiography/*radionuclide imagingAdultAgedFemaleFluorodeoxyglucose F18/diagnostic useGene DosageHumansImage Interpretation, Computer-AssistedIn Situ Hybridization, FluorescenceLung Neoplasms/*genetics/*radiography/*radionuclide imagingMaleMiddle AgedPositron-Emission TomographyRadiopharmaceuticals/diagnostic useReceptor, Epidermal Growth Factor/*geneticsRetrospective StudiesTomography, X-Ray Computed
Abstract
It has been suggested that a high EGFR gene copy number may be an indicator of good response to EGFR tyrosine kinase inhibitor therapy and a marker of poor prognosis in NSCLC. However, imaging features related to EGFR gene copy number status in adenocarcinoma are still unknown. We therefore retrospectively analyzed CT, FDG-PET, and histopathologic slides of surgical resected lung adenocarcinoma in 132 patients. Tumor characteristics on preoperative chest-CT, such as, GGO proportions, tumor diameters, and cavitation; FDG-PET SUV(max); and histopathologically determined differentiation degrees and tumor subtypes were evaluated. EGFR gene copy number status was categorized as FISH-positive or -negative. FISH-positivity was found in 53 patients (40.2%) and was significantly more frequent in tumors with a SUV(max)>7.0 (P=0.007). Furthermore, FISH-negativity was found to be more frequent in tumors with a GGO>50% (P=0.023) and diameter <15.5mm (P=0.006) on CT, or a well-differentiated histopathology (P=0.002). Moreover, the frequency of FISH-positivity increased as SUV(max) increased (P=0.0008) and as the proportion of GGO decreased (P=0.01). SUV(max)>7.0 was an independent predictor of FISH-positive results (odds ratio, 3.941; 95% CI, 1.691-9.182; P=0.01). In conclusion, a high SUV(max) on FDG-PET was significantly related to FISH-positive results. A high proportion of GGO, small tumor diameter on CT, and a well-differentiated histopathology were more frequent in FISH-negative adenocarcinomas.
ISSN
1872-8332 (Electronic)
Language
English
URI
http://hdl.handle.net/10371/61887
DOI
https://doi.org/10.1016/j.lungcan.2008.08.003
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College of Medicine/School of Medicine (의과대학/대학원)Thoracic Surgery (흉부외과학전공)Journal Papers (저널논문_흉부외과학전공)
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