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The mildly elevated serum bilirubin level is negatively associated with the incidence of end stage renal disease in patients with IgA nephropathy
DC Field | Value | Language |
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dc.contributor.author | Chin, Ho Jun | - |
dc.contributor.author | Cho, Hyun Jin | - |
dc.contributor.author | Lee, Tae Woo | - |
dc.contributor.author | Na, Ki Young | - |
dc.contributor.author | Oh, Kook Hwan | - |
dc.contributor.author | Joo, Kwon Wook | - |
dc.contributor.author | Yoon, Hyung Jin | - |
dc.contributor.author | Kim, Yon-Su | - |
dc.contributor.author | Ahn, Curie | - |
dc.contributor.author | Han, Jin Suk | - |
dc.contributor.author | Kim, Suhnggwon | - |
dc.contributor.author | Jeon, En Sil | - |
dc.contributor.author | Jin, Dong Chan | - |
dc.contributor.author | Kim, Yong-Lim | - |
dc.contributor.author | Park, Sun-Hee | - |
dc.contributor.author | Kim, Chan-Duck | - |
dc.contributor.author | Song, Young Rim | - |
dc.contributor.author | Kim, Seong Gyun | - |
dc.contributor.author | Kim, Yoon Goo | - |
dc.contributor.author | Lee, Jung Eun | - |
dc.contributor.author | Oh, Yoon Kyu | - |
dc.contributor.author | Lim, Chun Soo | - |
dc.contributor.author | Lee, Sang Koo | - |
dc.contributor.author | Chae, Dong-Wan | - |
dc.contributor.author | Cho, Won Yong | - |
dc.contributor.author | Kim, Hyoung Kyu | - |
dc.contributor.author | Jo, Sang-Kyung | - |
dc.date.accessioned | 2010-03-25T04:09:42Z | - |
dc.date.available | 2010-03-25T04:09:42Z | - |
dc.date.issued | 2009-02-12 | - |
dc.identifier.citation | J Korean Med Sci. 2009; 24 Suppl 1: S22-9 | en |
dc.identifier.issn | 1011-8934 (Print) | - |
dc.identifier.uri | https://hdl.handle.net/10371/61984 | - |
dc.description.abstract | Oxidative stress plays various roles in the development and progression of IgA nephropathy, while bilirubin is known as a potent antioxidant. We therefore hypothesized that serum bilirubin would be associated with renal prognosis in IgA nephropathy. The study subjects comprised 1,458 adult patients with primary IgA nephropathy in Korea. We grouped patients according to the following quartile levels of bilirubin: <0.4 mg/dL (Q1), 0.4-0.5 mg/dL (Q2), 0.6-0.7 mg/dL (Q3), and >0.8 mg/dL (Q4). The outcome data were obtained from the Korean Registry of end-stage renal disease (ESRD). Eighty patients (5.5%) contracted ESRD during a mean follow-up period of 44.9 months. The ESRD incidences were 10.7% in Q1, 8.2% in Q2, 2.8% in Q3, and 2.8% in Q4 (p<0.001). The relative risk of ESRD compared to that in Q1 was 0.307 (95% confidence interval [CI], 0.126-0.751) in Q3 and 0.315 (95% CI, 0.130-0.765) in Q4. The differences of ESRD incidence were greater in subgroups of males and of patients aged 35 yr or more, with serum albumin 4.0 g/dL or more, with normotension, with eGFR 60 mL/min/1.73 m(2) or more, and with proteinuria less then 3+ by dipstick test. In conclusion, higher bilirubin level was negatively associated with ESRD incidence in IgA nephropathy. | en |
dc.language.iso | en | - |
dc.publisher | Korean Academy of Medical Science | en |
dc.subject | Bilirubin/*blood | en |
dc.subject | Disease Progression | en |
dc.subject | Glomerular Filtration Rate | en |
dc.subject | Glomerulonephritis, IGA/*blood/complications | en |
dc.subject | Humans | en |
dc.subject | Hypertension/complications | en |
dc.subject | Incidence | en |
dc.subject | Kidney Failure, Chronic/*blood/complications | en |
dc.subject | Male | en |
dc.subject | Risk | en |
dc.subject | Risk Factors | en |
dc.subject | Treatment Outcome | en |
dc.title | The mildly elevated serum bilirubin level is negatively associated with the incidence of end stage renal disease in patients with IgA nephropathy | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 진호준 | - |
dc.contributor.AlternativeAuthor | 조현진 | - |
dc.contributor.AlternativeAuthor | 나기영 | - |
dc.contributor.AlternativeAuthor | 오국환 | - |
dc.contributor.AlternativeAuthor | 주권욱 | - |
dc.contributor.AlternativeAuthor | 윤형진 | - |
dc.contributor.AlternativeAuthor | 김연수 | - |
dc.contributor.AlternativeAuthor | 안규리 | - |
dc.contributor.AlternativeAuthor | 한진숙 | - |
dc.contributor.AlternativeAuthor | 김성권 | - |
dc.contributor.AlternativeAuthor | 전은실 | - |
dc.contributor.AlternativeAuthor | 진동찬 | - |
dc.contributor.AlternativeAuthor | 김용림 | - |
dc.contributor.AlternativeAuthor | 김성균 | - |
dc.contributor.AlternativeAuthor | 김윤구 | - |
dc.contributor.AlternativeAuthor | 박선희 | - |
dc.contributor.AlternativeAuthor | 김찬덕 | - |
dc.contributor.AlternativeAuthor | 송영림 | - |
dc.contributor.AlternativeAuthor | 이정은 | - |
dc.contributor.AlternativeAuthor | 오윤규 | - |
dc.contributor.AlternativeAuthor | 임천수 | - |
dc.contributor.AlternativeAuthor | 이상구 | - |
dc.contributor.AlternativeAuthor | 채동완 | - |
dc.contributor.AlternativeAuthor | 조원용 | - |
dc.contributor.AlternativeAuthor | 김형규 | - |
dc.contributor.AlternativeAuthor | 조상경 | - |
dc.identifier.doi | 10.3346/jkms.2009.24.S1.S22 | - |
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