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The mildly elevated serum bilirubin level is negatively associated with the incidence of end stage renal disease in patients with IgA nephropathy

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dc.contributor.authorChin, Ho Jun-
dc.contributor.authorCho, Hyun Jin-
dc.contributor.authorLee, Tae Woo-
dc.contributor.authorNa, Ki Young-
dc.contributor.authorOh, Kook Hwan-
dc.contributor.authorJoo, Kwon Wook-
dc.contributor.authorYoon, Hyung Jin-
dc.contributor.authorKim, Yon-Su-
dc.contributor.authorAhn, Curie-
dc.contributor.authorHan, Jin Suk-
dc.contributor.authorKim, Suhnggwon-
dc.contributor.authorJeon, En Sil-
dc.contributor.authorJin, Dong Chan-
dc.contributor.authorKim, Yong-Lim-
dc.contributor.authorPark, Sun-Hee-
dc.contributor.authorKim, Chan-Duck-
dc.contributor.authorSong, Young Rim-
dc.contributor.authorKim, Seong Gyun-
dc.contributor.authorKim, Yoon Goo-
dc.contributor.authorLee, Jung Eun-
dc.contributor.authorOh, Yoon Kyu-
dc.contributor.authorLim, Chun Soo-
dc.contributor.authorLee, Sang Koo-
dc.contributor.authorChae, Dong-Wan-
dc.contributor.authorCho, Won Yong-
dc.contributor.authorKim, Hyoung Kyu-
dc.contributor.authorJo, Sang-Kyung-
dc.date.accessioned2010-03-25T04:09:42Z-
dc.date.available2010-03-25T04:09:42Z-
dc.date.issued2009-02-12-
dc.identifier.citationJ Korean Med Sci. 2009; 24 Suppl 1: S22-9en
dc.identifier.issn1011-8934 (Print)-
dc.identifier.urihttp://hdl.handle.net/10371/61984-
dc.description.abstractOxidative stress plays various roles in the development and progression of IgA nephropathy, while bilirubin is known as a potent antioxidant. We therefore hypothesized that serum bilirubin would be associated with renal prognosis in IgA nephropathy. The study subjects comprised 1,458 adult patients with primary IgA nephropathy in Korea. We grouped patients according to the following quartile levels of bilirubin: <0.4 mg/dL (Q1), 0.4-0.5 mg/dL (Q2), 0.6-0.7 mg/dL (Q3), and >0.8 mg/dL (Q4). The outcome data were obtained from the Korean Registry of end-stage renal disease (ESRD). Eighty patients (5.5%) contracted ESRD during a mean follow-up period of 44.9 months. The ESRD incidences were 10.7% in Q1, 8.2% in Q2, 2.8% in Q3, and 2.8% in Q4 (p<0.001). The relative risk of ESRD compared to that in Q1 was 0.307 (95% confidence interval [CI], 0.126-0.751) in Q3 and 0.315 (95% CI, 0.130-0.765) in Q4. The differences of ESRD incidence were greater in subgroups of males and of patients aged 35 yr or more, with serum albumin 4.0 g/dL or more, with normotension, with eGFR 60 mL/min/1.73 m(2) or more, and with proteinuria less then 3+ by dipstick test. In conclusion, higher bilirubin level was negatively associated with ESRD incidence in IgA nephropathy.en
dc.language.isoen-
dc.publisherKorean Academy of Medical Scienceen
dc.subjectBilirubin/*blooden
dc.subjectDisease Progressionen
dc.subjectGlomerular Filtration Rateen
dc.subjectGlomerulonephritis, IGA/*blood/complicationsen
dc.subjectHumansen
dc.subjectHypertension/complicationsen
dc.subjectIncidenceen
dc.subjectKidney Failure, Chronic/*blood/complicationsen
dc.subjectMaleen
dc.subjectRisken
dc.subjectRisk Factorsen
dc.subjectTreatment Outcomeen
dc.titleThe mildly elevated serum bilirubin level is negatively associated with the incidence of end stage renal disease in patients with IgA nephropathyen
dc.typeArticleen
dc.contributor.AlternativeAuthor진호준-
dc.contributor.AlternativeAuthor조현진-
dc.contributor.AlternativeAuthor나기영-
dc.contributor.AlternativeAuthor오국환-
dc.contributor.AlternativeAuthor주권욱-
dc.contributor.AlternativeAuthor윤형진-
dc.contributor.AlternativeAuthor김연수-
dc.contributor.AlternativeAuthor안규리-
dc.contributor.AlternativeAuthor한진숙-
dc.contributor.AlternativeAuthor김성권-
dc.contributor.AlternativeAuthor전은실-
dc.contributor.AlternativeAuthor진동찬-
dc.contributor.AlternativeAuthor김용림-
dc.contributor.AlternativeAuthor김성균-
dc.contributor.AlternativeAuthor김윤구-
dc.contributor.AlternativeAuthor박선희-
dc.contributor.AlternativeAuthor김찬덕-
dc.contributor.AlternativeAuthor송영림-
dc.contributor.AlternativeAuthor이정은-
dc.contributor.AlternativeAuthor오윤규-
dc.contributor.AlternativeAuthor임천수-
dc.contributor.AlternativeAuthor이상구-
dc.contributor.AlternativeAuthor채동완-
dc.contributor.AlternativeAuthor조원용-
dc.contributor.AlternativeAuthor김형규-
dc.contributor.AlternativeAuthor조상경-
dc.identifier.doi10.3346/jkms.2009.24.S1.S22-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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