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Transcatheter arterial embolization therapy for a massive polycystic liver in autosomal dominant polycystic kidney disease patients

Cited 10 time in Web of Science Cited 20 time in Scopus
Authors
Park, Hayne Cho; Kim, Chi Weon; Ro, Han; Moon, Ju-Young; Oh, Kook-Hwan; Kim, Yonsu; Lee, Jung Sang; Yin, Yong Hu; Jae, Hwan Jun; Chung, Jin Wook; Ahn, Curie; Hwang, Young-Hwan
Issue Date
2009-03-10
Publisher
Korean Academy of Medical Science
Citation
J Korean Med Sci. 2009; 24(1): 57-61
Keywords
AgedCatheterizationCysts/*therapyEmbolization, Therapeutic/instrumentation/*methodsFemaleHepatic ArteryHumansLiver/pathology/physiologyLiver Diseases/pathology/*therapyPolycystic Kidney, Autosomal Dominant/diagnosis/*therapyPolyvinyl Alcohol/therapeutic useTomography, X-Ray Computed
Abstract
Polycystic liver is the most common extra-renal manifestation associated with autosomal dominant polycystic kidney disease (ADPKD), comprising up to 80% of all features. Patients with polycystic liver often suffer from abdominal discomfort, dyspepsia, or dyspnea; however, there have been few ways to relieve their symptoms effectively and safely. Therefore, we tried transcatheter arterial embolization (TAE), which has been used in treating hepatocellular carcinoma. We enrolled four patients with ADPKD in Seoul National University Hospital, suffering from enlarged polycystic liver. We embolized the hepatic arteries supplying the dominant hepatic segments replaced by cysts using polyvinyl alcohol particles and micro-coils. The patients were evaluated 12 months after embolization for the change in both liver and cyst volumes. Among four patients, one patient was lost in follow up and 3 patients were included in the analysis. Both liver (33%; 10%) and cyst volume (47.7%; 11.4%) substantially decreased in two patients. Common adverse events were fever, epigastric pain, nausea, and vomiting. We suggest that TAE is effective and safe in treating symptomatic polycystic liver in selected ADPKD patients.
ISSN
1598-6357 (Electronic)
Language
English
URI
http://hdl.handle.net/10371/62000
DOI
https://doi.org/10.3346/jkms.2009.24.1.57
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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