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The incidence and clinical implication of sputum with positive acid-fast bacilli smear but negative in mycobacterial culture in a tertiary referral hospital in South Korea

Cited 19 time in Web of Science Cited 19 time in Scopus
Authors
Lee, Jae Seok; Kim, Eui-Chong; Joo, Sei Ick; Lee, Sang-Min; Yoo, Chul-Gyu; Kim, Young Whan; Han, Sung Koo; Shim, Young-Soo; Yim, Jae-Joon
Issue Date
2008-10-29
Publisher
Korean Academy of Medical Science
Citation
J Korean Med Sci. 2008; 23(5): 767-71
Keywords
Bacterial Typing TechniquesBacteriological TechniquesFalse Positive ReactionsHumansIncidenceKoreaMycobacterium/*metabolismRetrospective StudiesSputum/*microbiologyTuberculosis, Pulmonary/diagnosis/epidemiology/microbiology
Abstract
Although it is not rare to find sputum that is positive acid-fast bacilli (AFB) smear but subsequent culture fails to isolate mycobacteria in clinical practice, the incidence and clinical implication of those sputa from new patients has not been clearly elucidated. The aim of this study was to determine the incidence and clinical implication of sputum with positive AFB smear but negative in mycobacterial culture. All sputa that were positive AFB smear requested during diagnostic work up for new patients visiting Seoul National University Hospital from 1 January 2005 through 31 December 2006 were included. Sputa producing a positive AFB smear but negative mycobacterial culture were classified into one of four categories: laboratory failure to isolate mycobacteria, false positive AFB smear, pathogen may show a positive AFB smear other than mycobacteria, and indeterminate results. Out of 447 sputa with a positive AFB smear, 29 (6.5%) failed to culture any organism. Among these 29 sputa, 18 were caused by laboratory failure to isolate mycobacteria, six were false positive smears, and five indeterminate. Although most sputum with a positive AFB smear but negative culture could be classified as a laboratory failure, clinicians should consider the possibility of false positive AFB smear.
ISSN
1011-8934 (Print)
1011-8934 (Linking)
Language
English
URI
http://hdl.handle.net/10371/62007
DOI
https://doi.org/10.3346/jkms.2008.23.5.767
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College of Medicine/School of Medicine (의과대학/대학원)Laboratory Medicine (검사의학전공)Journal Papers (저널논문_검사의학전공)
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