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College of Dentistry/School of Dentistry (치과대학/치의학대학원)
Dept. of Dentistry (치의학과)
Journal Papers (저널논문_치의학과)
Dibenzocyclooctadiene Lignans from Schisandra chinensis protect primary cultures of rat cortical cells from glutamate-induced toxicity
- Issue Date
- 2004
- Publisher
- Wiley-Blackwell
- Citation
- Journal of Neuroscience Research 76:397–405
- Keywords
- dibenzocyclooctadiene lignans ; excitotoxic cell damage ; glutathione defense system ; neuroprotective activity ; Schisandra chinensis
- Abstract
- A methanolic extract of dried Schisandra fruit (Schisandra
chinensis Baill.; Schisandraceae) significantly attenuated
the neurotoxicity induced by L-glutamate in primary cultures
of rat cortical cells. Five dibenzocyclooctadiene lignans
(deoxyschisandrin, gomisin N, gomisin A, schisandrin,
and wuweizisu C) were isolated from the methanolic extract;
their protective effects against glutamate-induced
neurotoxicity were then evaluated. Among the five lignans,
deoxyschisandrin, gomisin N, and wuweizisu C significantly
attenuated glutamate-induced neurotoxicity as measured
by 1) an inhibition in the increase of intracellular [Ca2 ]; 2)
an improvement in the glutathione defense system, the
level of glutathione, and the activity of glutathione peroxidase;
and 3) an inhibition in the formation of cellular peroxide.
These results suggest that dibenzocyclooctadiene lignans
from Schisandra chinensis may possess therapeutic
potential against oxidative neuronal damage induced by
excitotoxin.
- ISSN
- 0360-4012
- Language
- English
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