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High prevalence of hepatitis B virus infection in patients with B-cell non-Hodgkin's lymphoma in Korea
Cited 54 time in
Web of Science
Cited 66 time in Scopus
- Authors
- Issue Date
- 2008-04-23
- Publisher
- Wiley-Blackwell
- Citation
- J Med Virol. 2008 ;80(6):960-6.
- Keywords
- Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; DNA, Viral/analysis ; Female ; Genes, Viral/genetics ; Hepatitis B/*complications/*epidemiology ; Hepatitis B Core Antigens/analysis ; Hepatitis B Surface Antigens/analysis ; Hepatitis B virus/genetics/isolation & purification ; Hepatitis C/epidemiology ; Humans ; Immunohistochemistry ; Korea/epidemiology ; Leukocytes, Mononuclear/virology ; Lymphoma, B-Cell/*complications/epidemiology/virology ; Lymphoma, Non-Hodgkin/*complications/epidemiology/virology ; Male ; Middle Aged ; Prevalence ; Stomach Neoplasms/complications/epidemiology
- Abstract
- This study assessed the association of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection with non-Hodgkin's lymphoma in a highly HBV-endemic area. The prevalence of either HBV or HCV infection in 235 patients with non-Hodgkin's lymphoma was compared with that of an age- and sex-matched hospital control group of 235 patients. The prevalence of HBV infection was higher in B-cell non-Hodgkin's lymphoma (15.5%) than control (8.1%), but the prevalence of HCV infection in the non-Hodgkin's lymphoma patients (2.1%) and control group (3%) was similar. HBV prevalence increased significantly with age in the B-cell non-Hodgkin's lymphoma patients. The presence of HBV proteins and DNA in lymphoma tissues and peripheral blood mononuclear cells (PBMCs) from HBV-infected non-Hodgkin's lymphoma patients was also investigated using immunohistochemistry and PCR. HBV DNA was frequently detected in PBMCs from HBV-infected non-Hodgkin's lymphoma patients, but HBV antigens were not. Therefore, HBV infection, but not HCV infection, was associated with B-cell non-Hodgkin's lymphoma in Korea, suggesting a possible role for HBV in the development of non-Hodgkin's lymphoma.
- ISSN
- 0146-6615 (Print)
- Language
- English
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