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Functional analysis of T-cell antigen 4-1BB in activated intestinal intra-epithelial T lymphocytes

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Authors
Zhou, Zhen; Pollok, Karen E; Kim, Kack K; Kim, Young-June; Kwon, Byoung S
Issue Date
1994
Publisher
Elsevier
Citation
Immunology Letters. 41, 177-184.
Keywords
4-1BBIntra-epithelial lymphocytephenotype/function
Abstract
The 4-1BB antigen has been recently demonstrated to be a 30 kDa inducible T-cell antigen and is expressed on the cell surface of activated splenic T cells and thymocytes. This novel T-cell antigen also associates physically with the T cell-specific protein tyrosine kinase, p56lck. We show here that the inducible T-cell antigen 4-1BB is expressed on activated intestinal intra-epithelial T lymphocytes (IEL). After activation, or in the presence of IL-2, the activated IELs showed higher levels of 4-1BB. Functional studies revealed that the activated IELs triggered with anti-4-1BB monoclonal antibody could enhance the level of IEL cytotoxicity against anti-CD3-secreting hybridoma cells. Cross-linking of anti-4-1BB antibody also enhanced the proliferation of IELs. These results suggest that the inducible antigen 4-1BB has broad biological functions which not only play a role in activated splenic T cells and thymocytes but also in the mucosal immune system.
ISSN
0165-2478
Language
English
URI
http://hdl.handle.net/10371/62209
DOI
https://doi.org/10.1016/0615-2478(94)90129-5
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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