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GABAergic amd serotonergic modulation of calcium currents in rat trigeminal motoneurons

Cited 6 time in Web of Science Cited 6 time in Scopus
Authors
Park, Kyungpyo; Oh, Seog Bae; Piao, Zheng Gen; Shin, Sang Sup; Ren, Dong Jun; Kim, Joong Soo
Issue Date
2003-09
Publisher
Elsevier
Citation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 309 (2003), 58-65.
Keywords
trigeminal motoneuronshigh voltage-activated calcium channelsreverse transcription-polymerization chain reactionserotoninGABA
Abstract
We investigated the effects of a GABAB agonist baclofen, and serotonin, on the high voltage-activated Ca channel (HVACC) currents in trigeminal motoneurons. Immunohistochemical and reverse transcription-polymerization chain reaction (RT-PCR) studies demonstrated the expression of α1C, α1B, α1A, and α1E subunits in the trigeminal motoneurons, which form L-, N-, P/Q-, and R-type Ca channels, respectively. By use of specific Ca blockers, it was found that N-type (38%), P/Q-type (27%), L-type (16 %), and R-type Ca currents (19%) contribute to HVACC IBa. Baclofen inhibited HVACC IBa in the majority of trigeminal motoneurons tested (n=15 outof 16), whereas serotonin only did in a small population (n=5 outof 18). The IBa inhibition by baclofen and serotonin was associated with slowing of activation kinetics, relieved by strong prepulse, and prevented by N-ethylmaleimide (NEM), indicative of mediation of Gi/Go. These data provide evidence that GABAergic and serotonergic inputs to trigeminal motoneurons regulate neuronal activities through the inhibition of HVACC currents.
ISSN
0006-291X
Language
English
URI
http://hdl.handle.net/10371/62230
DOI
https://doi.org/10.1016/S0006-291X(03)01527-4
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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