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Matrix metalloproteinase-9 promoter polymorphisms in Korean patients with systemic lupus erythematosus

Cited 8 time in Web of Science Cited 8 time in Scopus
Authors
Lee, Yun Jong; Woo, Mijung; Nam, Jung-Hyun; Baek, Jinah; Im, Churl Hyun; Lee, Eun Young; Lee, Eun Bong; Park, Kyung Sook; Song, Yeong Wook
Issue Date
2008-06-24
Publisher
Elsevier
Citation
Hum Immunol. 2008 ;69(6):374-9.
Keywords
AdultAgedFemaleGene FrequencyGenotypeHumansKoreaLupus Erythematosus, Systemic/blood/*geneticsMaleMatrix Metalloproteinase 9/*geneticsMiddle AgedPolymorphism, Genetic*Promoter Regions, Genetic
Abstract
To investigate the association between functional promoter polymorphisms of matrix metalloproteinase-9 (MMP-9) and systemic lupus erythematosus (SLE), we analyzed MMP-9 promoter -1562 C>T and MMP-9 -90 (CA)(n) repeat polymorphisms in 135 Korean SLE patients (mean age, 34.7 years; 124 female and 11 male) and in 135 gender- and age-matched healthy controls (mean age, 35.4 years). Clinical and laboratory findings were collected during the follow-up period (mean, 63.5 months; range, 3-252 months), and Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) Damage Indexes were calculated. The levels of total MMP-9 were measured in sera of SLE patients and controls by enzyme-linked immunoabsorbent assay. The serum levels of MMP-9 in SLE patients were significantly lower than those of controls (mean +/- standard error of the mean, 1421.6+/-177.4 vs 3731.4+/-441.4 ng/ml, p=1.2 x 10(-5) by t test). Both functional polymorphisms were under the Hardy-Weinberg equilibrium state except (CA)(n) repeat polymorphisms in SLE patients (p=2.6 x 10(-5) by chi(2) goodness-of-fit test). The distribution of the MMP-9 promoter polymorphisms or haplotypes was not significantly different in SLE patients and controls. However the frequency of alleles with low numbers of CA repeats (n<21, 11.9% vs 7.0%, p=0.06 by the chi(2) test; odds ratio=1.78, 95% confidence interval=0.99-3.20) and the prevalence of low CA repeats homozygote tended to be higher in patients than in controls (5.2% vs 0.7%, p=0.07 by logistic regression, odds ratio=7.29, 95% confidence interval=0.88-60.10) in the recessive model. No relationship was found between MMP-9 polymorphisms and clinical features or damage as indicated by SLICC/ACR Damage Index in the study subjects. These results suggest that genetic polymorphisms of the MMP-9 promoter regions are not associated with the development of SLE in Korea.
ISSN
0198-8859 (Print)
Language
English
URI
http://hdl.handle.net/10371/62323
DOI
https://doi.org/10.1016/j.humimm.2008.03.005
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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