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The Effects of Immobilization Stress on the Synthesis and the Catabolism of Dopamine and Norepinephrine in the Rat Hypothalamus
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeong, Do-Un | - |
dc.contributor.author | Suh, Yoo Hun | - |
dc.contributor.author | Woo, Jong Inn | - |
dc.contributor.author | Lee, Chung Kyoon | - |
dc.date.accessioned | 2009-08-06T05:13:23Z | - |
dc.date.available | 2009-08-06T05:13:23Z | - |
dc.date.issued | 1992-12 | - |
dc.identifier.citation | Seoul J Med, Vol.33 No.4, pp. 291-300 | - |
dc.identifier.issn | 0582-6802 | - |
dc.identifier.uri | https://hdl.handle.net/10371/6254 | - |
dc.description.abstract | Immobilization stress was adopted as a prototype stress model for studying
the effects of stress on dopaminergic and noradrenergic neuronal activity in the rat hypothalamus. Norepinephrine content was significantly increased after 4 hours of immobilization stress. Also, the turnover rates of both dopamine and norepinephrine were found to be significantly increased after the stress, providing the evidence of increased synthesis rates of both neurotransmitters. These findings were consistent with the increase in plasma corticosterone and catecholamine levels. The activities of tyrosine hydroxylase and dopamine-j1-hydroxylase, the synthesizing enzymes for catecholamines, were significantly increased after the stress, while that of monoamine oxidase, the catabolizing enzyme, did not change to a significant degree at all. Kinetic analysis of tyrosine hydroxylase, the rate-limiting step in catecholamine biosynthesis, revealed that Vmax was significantly increased after the stress without significant change of Km. These findings suggest that dopamine and norepinephrine may playa significant role in mediating stress responses by increasing their neuronal activities. | - |
dc.language.iso | en | - |
dc.publisher | Seoul National University College of Medicine | - |
dc.subject | Immobilization stress | - |
dc.subject | Dopamine | - |
dc.subject | Norepinephrine | - |
dc.subject | Turnover rate | - |
dc.subject | Tyrosine hydroxylase | - |
dc.subject | Dopamine-β-hydroxylase | - |
dc.subject | Monoamine oxidase | - |
dc.title | The Effects of Immobilization Stress on the Synthesis and the Catabolism of Dopamine and Norepinephrine in the Rat Hypothalamus | - |
dc.type | SNU Journal | - |
dc.contributor.AlternativeAuthor | 정도언 | - |
dc.contributor.AlternativeAuthor | 서유헌 | - |
dc.contributor.AlternativeAuthor | 우종인 | - |
dc.contributor.AlternativeAuthor | 이정균 | - |
dc.citation.journaltitle | 서울 의대 잡지 | - |
dc.citation.journaltitle | 서울 의대 학술지 | - |
dc.citation.journaltitle | Seoul Journal of Medicine | - |
dc.citation.endpage | 300 | - |
dc.citation.number | 4 | - |
dc.citation.pages | 291-300 | - |
dc.citation.startpage | 291 | - |
dc.citation.volume | 33 | - |
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