Publications
Detailed Information
Possible Mechanism on Enhanced Blood Compatibility, Biostability, and Anticalcification of Sulfonated Polyethyleneoxide-Grafted Polyurethane
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Han, Dong-Keun | - |
dc.contributor.author | Lee, Kyu-Back | - |
dc.contributor.author | Choi, Jin-Wook | - |
dc.contributor.author | Kim, Cheol-Sang | - |
dc.contributor.author | Kim, Hee-Chan | - |
dc.contributor.author | Kim, Young-Ha | - |
dc.contributor.author | Min, Byoung-Goo | - |
dc.date.accessioned | 2009-08-06T05:23:35Z | - |
dc.date.available | 2009-08-06T05:23:35Z | - |
dc.date.issued | 1992-12 | - |
dc.identifier.citation | Seoul J Med, Vol.33 No.4, pp. 317-326 | - |
dc.identifier.issn | 0582-6802 | - |
dc.identifier.uri | https://hdl.handle.net/10371/6261 | - |
dc.description.abstract | To investigate the correlation between blood compatibility and
biostability as well as the calcification-resistance of polymers, the surface of polyurethane (PU) was grafted with hydrophilic polyethyleneoxide (PEO), and further negatively charged sulfonate groups (S03) to produce PU-PEOIOOO and PU-PEOIOOOS03, respectively. PEO-S03 grafted PU surface showed great smoothness and high hydrophilicity. PU-PEOIOOO-S03 was much more blood compatible than untreated PU and PU-PEOlOOO from the results of in vitro platelet adhesion test and blood clotting times and ex vivo occlusion times. After 6 months implantation in rats, the degree of surface cracking and calcification on explanted PUs was decreased in the following order: PU ) PU-PEOIOOO ) PU-PEOlOOO-S03, meaning that PU-PEOlOOO-S03 is most promising as a biostable and calcification-resistant polymer. It is suggested that the more blood compatible modified PUs are, the more biostable and calcification-resistant. Such superior blood compatibility, biostability, and anticalcification of PU-PEOlOO 0-S03 might be attributed to the synergistic effect of nonadhesive and mobile PEO and negative sulfonate acid groups. Therefore, surface-modified PU-PEO-S03is expected to be useful for blood/tissue contacting biomedical material. | - |
dc.language.iso | en | - |
dc.publisher | Seoul National University College of Medicine | - |
dc.subject | Polyurethane | - |
dc.subject | Surface modification | - |
dc.subject | PU-PEO-S₃ | - |
dc.subject | Smoothness | - |
dc.subject | Hydrophilicity | - |
dc.subject | Blood compatibility | - |
dc.subject | Biostability | - |
dc.subject | Anticalcification | - |
dc.title | Possible Mechanism on Enhanced Blood Compatibility, Biostability, and Anticalcification of Sulfonated Polyethyleneoxide-Grafted Polyurethane | - |
dc.type | SNU Journal | - |
dc.contributor.AlternativeAuthor | 한동근 | - |
dc.contributor.AlternativeAuthor | 이규백 | - |
dc.contributor.AlternativeAuthor | 최진욱 | - |
dc.contributor.AlternativeAuthor | 김철상 | - |
dc.contributor.AlternativeAuthor | 김희찬 | - |
dc.contributor.AlternativeAuthor | 김영하 | - |
dc.contributor.AlternativeAuthor | 민병구 | - |
dc.citation.journaltitle | 서울 의대 잡지 | - |
dc.citation.journaltitle | 서울 의대 학술지 | - |
dc.citation.journaltitle | Seoul Journal of Medicine | - |
dc.citation.endpage | 326 | - |
dc.citation.number | 4 | - |
dc.citation.pages | 317-326 | - |
dc.citation.startpage | 317 | - |
dc.citation.volume | 33 | - |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.