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A genome-wide Asian genetic map and ethnic comparison: the GENDISCAN study

Cited 15 time in Web of Science Cited 15 time in Scopus
Authors
Ju, Young Seok; Park, Hansoo; Lee, Mi-Kyeong; Kim, Jong-Il; Sung, Joohon; Cho, Sung-Il; Seo, Jeong-Sun
Issue Date
2008-11-26
Publisher
BioMed Central
Citation
BMC Genomics 2008, 9:554-563
Keywords
AsiaChromosome Mapping/*methodsEthnic Groups/*geneticsGenetic Markers*Genome, Human*Linkage (Genetics)MeiosisMicrosatellite RepeatsRecombination, Genetic
Abstract
BACKGROUND: Genetic maps provide specific positions of genetic markers, which are required for performing genetic studies. Linkage analyses of Asian families have been performed with Caucasian genetic maps, since appropriate genetic maps of Asians were not available. Different ethnic groups may have different recombination rates as a result of genomic variations, which would generate misspecification of the genetic map and reduce the power of linkage analyses. RESULTS: We constructed the genetic map of a Mongolian population in Asia with CRIMAP software. This new map, called the GENDISCAN map, is based on genotype data collected from 1026 individuals of 73 large Mongolian families, and includes 1790 total and 1500 observable meioses. The GENDISCAN map provides sex-averaged and sex-specific genetic positions of 1039 microsatellite markers in Kosambi centimorgans (cM) with physical positions. We also determined 95% confidence intervals of genetic distances of the adjacent marker intervals. Genetic lengths of the whole genome, chromosomes and adjacent marker intervals are compared with those of Rutgers Map v.2, which was constructed based on Caucasian populations (Centre d'Etudes du Polymorphisme Humain (CEPH) and Icelandic families) by mapping methods identical to those of the GENDISCAN map, CRIMAP software and the Kosambi map function. Mongolians showed approximately 1.9 fewer recombinations per meiosis than Caucasians. As a result, genetic lengths of the whole genome and chromosomes of the GENDISCAN map are shorter than those of Rutgers Map v.2. Thirty-eight marker intervals differed significantly between the Mongolian and Caucasian genetic maps. CONCLUSION: The new GENDISCAN map is applicable to the genetic study of Asian populations. Differences in the genetic distances between the GENDISCAN and Caucasian maps could facilitate elucidation of genomic variations between different ethnic groups.
ISSN
1471-2164 (Electronic)
Language
English
URI
http://hdl.handle.net/10371/62749
DOI
https://doi.org/10.1186/1471-2164-9-554
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Biochemistry & Molecular Biology (생화학교실)Journal Papers (저널논문_생화학교실)
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