S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 03 No.3 (1962)
금붕어의 안구돌출에 관한 실험적 연구
The Production of Experimental Exophthalmos in Gold Fish
- Issue Date
- 서울대학교 의과대학
- Seoul J Med 1962;3(3):51-55
- Gold fish (Carassius auratus, var. japonicus) were used for the demonstration of the exophthalmos-producing
substance in the serum of a patient suffering
from thyrotoxicosis with exophthalmos. The exophthalmic
response of the fish was determined by measuring
the intercorneal distance by the use of a micrometer
before and after the injections of test materials, and
the percentage change in that distance was calculated.
The responsiveness of the fish was partly controlled
by the injections of normal saline. normal human
serum. and commercially prepared anterior pituitary
hormone with and without prednisolone added.
The normal saline injection did not provoke any
resonse in fish. The normal human serum produced
transient enophthalmos. whereas the serum from a
patient suffering from toxic goiter with exophthalmos
produced definite exophthalmos.
The anterior pituitary hormone elicited marked exophthalmic
response. There was no correlation between
the degree of response and the dosage level of the
Addition of prednisolone to this hormone preparation
seemed to inhibit the exophthalmogenic effect of the
anterior pituitary hormone.
This method of the production of experimental exophthalmos
in gold fish might be used for the demonstration
of the exophthalmos-producing substance in the
serum of the exophthalmic patient.