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Comparison of a pulsatile blood pump and a peristaltic roller pump during hemoperfusion treatment in a canine model of paraquat poisoning

Cited 6 time in Web of Science Cited 7 time in Scopus
Authors
Lee, Jung Chan; Park, Chan Young; Choi, Seong Wook; Kim, Jeong Chul; Lim, Ki Moo; Kim, Kyuseok; Jung, Sung Koo; Kwak, Young Ho; Shin, Sang Do; Jo, Ik Joon; Suh, Gil Joon; Min, Byoung Goo
Issue Date
2008-07-22
Publisher
Wiley-Blackwell
Citation
Artif Organs. 2008 ;32(7):541-6.
Keywords
AnimalsCharcoal/therapeutic useDogs*Heart-Assist DevicesHemodynamicsHemolysisHemoperfusion/*instrumentationParaquat/*blood/*poisoningPulsatile Flow
Abstract
This study examined the treatment efficacy and the damage to the blood during hemoperfusion for treating paraquat poisoning using two blood pump mechanisms. Paraquat-poisoned animal models were prepared. A conventional hemodialysis machine, AK90, with a peristaltic roller pump and a cardiopulmonary support system, T-PLS, with a pulsatile blood pump were used during the animal experiments. A total of 12 dogs were treated with hemoperfusion using a charcoal column. Six dogs were treated with hemoperfusion and T-PLS, and the other six were treated with AK90. A paraquat dose of 30 mg/kg was administrated by an intravenous injection. Both pumps maintained blood flow rates of 125 mL/min measured by an ultrasonic flowmeter. For anticoagulation, heparin was administrated by an initial bolus (250 IU/kg) and a continuous injection (100 IU/kg/h). During the experiments, T-PLS and AK90 showed a similar toxin removal efficacy. Both devices decreased the plasma paraquat concentration to 10% of the initial dose within 4-h hemoperfusion. The two pumps showed similar hemolysis properties with acceptable levels. Although T-PLS was developed as a cardiopulmonary bypass system, it can also be used as a hemoperfusion treatment device.
ISSN
1525-1594 (Electronic)
0160-564X (Print)
Language
English
URI
http://hdl.handle.net/10371/63040
DOI
https://doi.org/10.1111/j.1525-1594.2008.00582.x
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College of Medicine/School of Medicine (의과대학/대학원)Emergency Medicine (응급의학전공)Journal Papers (저널논문_응급의학전공)
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