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College of Medicine/School of Medicine (의과대학/대학원)
Preventive Medicine (예방의학전공)
Journal Papers (저널논문_예방의학전공)
Serum high-density lipoprotein cholesterol and breast cancer risk by menopausal status, body mass index, and hormonal receptor in Korea
- Issue Date
- 2009-02-05
- Publisher
- American Association for Cancer Research
- Citation
- Cancer Epidemiol Biomarkers Prev. 2009;18(2):508-15.
- Keywords
- Breast Neoplasms/*blood/epidemiology ; Case-Control Studies ; Cholesterol, HDL/*blood ; Female ; Humans ; Korea/epidemiology ; Logistic Models ; Menopause/*blood ; Middle Aged ; Questionnaires ; Receptors, Estrogen/*blood ; Receptors, Progesterone/*blood ; Risk Factors ; Body Mass Index
- Abstract
- High-density lipoprotein cholesterol (HDL-C) has been suggested to be associated with breast cancer. However, the roles of HDL-C and hypertriglyceridemia on breast cancer still have been controversial. The goal of this study was to investigate the association between HDL-C with breast cancer risk, stratifying by menopausal status, and body mass index. The hormonal receptor status of breast has been proposed to modify the effect of HDL-C on breast cancer. Multicenter hospital-based case-control study was conducted from November 2004 to December 2005 in Korea. After one to two individual matchings by age (+/-5 years) and menopausal status, 690 cases and 1,380 controls were included in the analysis. Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated by conditional, unconditional, and multinomial logistic regressions. Protective effect of HDL-C on breast cancer was only observed among premenopausal women with an OR (95% CI) of 0.49 (0.33-0.72) for HDL-C > or = 60 versus <50 mg/dL (P(trend) < 0.01). Only nonobese premenopausal women had a significant decreased risk (OR, 0.34; 95% CI, 0.22-0.53). OR (95% CI) of low HDL-C (<50 mg/dL) and high triglyceride (TG; > or = 150 mg/dL) category was 2.20 (1.32-3.67) on estrogen receptor-negative and progesterone receptor-negative breast cancer compared with high HDL-C (> or = 50 mg/dL) and low TG (<150 mg/dL) category. This study suggests that higher level of HDL-C may reduce breast cancer risk among premenopausal women. Estrogen receptor-negative and progesterone receptor-negative breast cancer was associated with dyslipidemia, which implicates that association among HDL-C, TG, and breast cancer may be modified by receptor status.
- ISSN
- 1055-9965 (Print)
- Language
- English
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