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The heme oxygenase-1 genotype is a risk factor to renal impairment of IgA nephropathy at diagnosis, which is a strong predictor of mortality

Cited 19 time in Web of Science Cited 23 time in Scopus
Authors
Chin, Ho Jun; Cho, Hyun Jin; Lee, Tae Woo; Na, Ki Young; Yoon, Hyung Jin; Chae, Dong-Wan; Kim, Suhnggwon; Jeon, Un Sil; Do, Jun-Young; Park, Jong-Won; Yoon, Kyung-Woo; Shin, Young-Tai; Lee, Kang Wook; Na, Ki-Ryang; Cha, Dae Ryong; Kang, Young Sun
Issue Date
2009-02-12
Publisher
Korean Academy of Medical Science
Citation
J Korean Med Sci. 2009 Jan;24 Suppl:S30-7. Epub 2009 Jan 28.
Keywords
AdultDisease ProgressionFemaleGene FrequencyGenotypeGlomerular Filtration RateGlomerulonephritis, IGA/*genetics/mortality/*pathologyHeme Oxygenase-1/*geneticsHumansMaleMiddle AgedOdds RatioPolymorphism, GeneticPromoter Regions, GeneticRisk Factors
Abstract
The induction of heme oxygenase-1 (HO-1) ameliorates oxidative stress and inflammatory process, which play important roles in IgA nephropathy. We hypothesized length polymorphism in the promoter region of the HO-1 gene, which is related to the level of gene transcription, is associated with disease severity of IgA nephropathy. The subjects comprised 916 patients with IgA nephropathy and gene data. Renal impairment was defined as an estimated glomerular filtration rate less than 60 mL/min/1.73 m(2) at diagnosis. The short (S: <23), medium (M: 23-28), and long (L: >28) (GT) repeats in the HO-1 gene was determined. The frequencies of S/S, S/M, M/M, S/L, L/M, and L/L genotypes were 7.2%, 6.9%, 3.1%, 30.8%, 22.7%, and 29.4%, respectively. The baseline characteristics were not different. In the S/S genotypic group, the renal impairment rate was 18.2%, which was lower than 32.2% in the group with M/M, L/M, or L/L genotype. The odds ratio of renal impairment in S/S genotype, compared to that in M/M, L/M, or L/L genotype, was 0.216 (95% confidence interval, 0.060-0.774, p=0.019). The HO-1 gene promoter length polymorphism was related to the renal impairment of IgA nephropathy at diagnosis, which is an important risk factor for mortality in IgA nephropathy patients.
ISSN
1011-8934 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19194559

http://synapse.koreamed.org/Synapse/Data/PDFData/0063JKMS/jkms-24-S30.pdf

http://hdl.handle.net/10371/63096
DOI
https://doi.org/10.3346/jkms.2009.24.S1.S30
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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