SHERP

기관지상피화생에 관한 실험적 연구
Experimental Studies on Metaplasia in Tracheo-bronchial Epithelium of Rabbit,

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Authors
함의근
Issue Date
1965-12
Publisher
서울대학교 의과대학
Citation
Seoul J Med 1965;6(4):55-71
Abstract
Bronchial epithelial metaplasia of the rabbits was
experimentally studied by means of long-standing
repeated inhalation of formalin gas, Used animals were
healthy adult rabbits weighing about 1,5 kgm, and
having _ no pulmonary diseases. Formalin gas was
administered according to Hollands" method and eleven
sections were taken from the definite sites of the
trachea and both main bronchi.
The following results and conclusions were made.
1. In the group which was not exposed to the formalin
gas inhalation typical squamous metaplasia of bronchial
epithelium in the course of time was not observed.
2. In the group which was exposed to the repeated
formalin gas inhalation inflammatory changes, degenerative
changes, regenerative findings especially
metaplastic change and complicated reparative changes
were observed: ® In the group which was exposed to the repeated
formalin gas inhalation, a certain serial changes;
i.e., destruction and desquamation of columnar
epithelium, newgrowth of single layered squamous
epithelium and proliferation of multilayered squamous
epithelium (metaplasia) were observed in early
stage(l-18 experimental days).
(Q) In the group which was exposed to the repeated
formalin gas inhalation various changes ranging from
degeneration, destruction or desquamation of
squamous epithelium to regenerated columnar epithelium,
and also ranging from relatively normalcolumnar
epithelium to typical stratified squamous
metaplasia were observed in early phase of middle
stage(l9-43 experimental days).
© In the group which was exposed to the repeated
formalin gas inhalation various gradational changes
described above were observed in the trachea and
bronchi, and moreover, papillary projections of
bronchial metaplastic epithelium were observed in a
considerable proportion, and also characteristic
alveolar epithelialation was observed in one case, in
late phase of middle stage(44-64 experimental days).
@ In the group which was exposed to the repeated
formalin gas inhalation the earliest case showed
rather typical squamous metaplasia of trachea and
bronchi after five hours of actual exposure.
3. In the group which was exposed to the long-continued
and repeated formalin gas inhalation(65-283 experimental
days) a certain serial changes described
above were observed, and in this group more marked
keratinizing stratified squamous metaplasia and conspicuous
papillary projection of metaplastic epithelium
were observed.
In most cases, moderate to marked bronchiectatic
changes were observed in lower parts of the lungs.
4. In the group which was exposed to the repeated
formalin gas inhalation findings consistent with atypical
metaplasia or carcinoma in situ were not observed.
5. In the group which was exposed to the repeated
formalin gas inhalation the incidence of epithelial
metaplasia of trachea and bronchi was approximately
80 per cent. Male rabbit (92% positive) showed
definite high positivity compared to the female rabbit
(approximately 69% positivity).
6. In the group which was exposed for long time(96% positive) metaplastic tendency was apparantly increased
compared to that of short-term exposure group (62%
positive).
7. Observations on distribution and range of metaplasia
failed to indicate the site preponderance in trachea
and bronchi.
8. In the group which was exposed to the repeated formalingas
inhalation invasiveness of metaplasia was relative
ly high and it was especially conspicuous in the group
of long-continued exposure.
Language
Korean
URI
http://hdl.handle.net/10371/6317
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Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 06 No.4 (1965)
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