파상풍병인에 있어서의 파상풍용혈소의 역할
A Pccsible Role of Tetanolysin in the Pathogenesis of Tetanus

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서울대학교 의과대학
Seoul J Med 1968;9(2):1-13
The main clinical signs of tetanus reman within the"
limit of neurological manifestations such as difficulties in
swallowing, trismus and/or opisthotonus, probably being.
induced by tetanospasmin which seems to be released from·
the organisms grown in tissue. Regarding the toxigenicity
of Cl. tetani, the tetanolysin is also known as one'
of the toxic substances, detectable in vitro during the'
growth of the organisms. It hemolyses erythrocytes of
human and various animals, necrotizes the tissues and;
also produces cardiotoxic effects to rabbits and guinea.
It may be assumed that the tetanolysin might take a'
part as a pathogenetic factor, in association with tetanospasmin
during the course of tatanus. No significant
work on tetanolysin, however, has been reported in rela-:
tion to pathogenesis of tetanus.
The author designed an experiment to observe the'
conditions in vitro as to the hemolytic activities of thee
culture fluid of CI. tetani which may be regarded as'
a mixture of tetanolysin, tetanospasmin and so on.
According to the observations, the optimal conditions
for the hemolytic activities of the culture fluid likely tobe
induced by tetanolysin were found as follows.
a) The optimal pH was 8. 3.
b) The oxidation of the hemolytic agents in culture'
fluid reduced its activity instantly.
c) The cholesterol and the like inhibited the hemolytic:
d) The hemolytic activity of the culture fluid wasneutralized
by antistreptolysin 0, and vice versa
Considering the result obtained, the hemolytic activity'
of the culture fluid of CI. tetani are limited by the'
conditions which may not possibly be provided by theliving
environment of tissues; thus, an assumption that
the hemolytic activities of the metabolic products from.
CI. tetani including tetanolysin may play a role in the;
courese of the disease can hardly be made.
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 09 No.2 (1968)
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