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Association between the alpha-2C-adrenergic receptor gene and attention deficit hyperactivity disorder in a Korean sample
DC Field | Value | Language |
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dc.contributor.author | Cho, Soo-Churl | - |
dc.contributor.author | Kim, Jae-Won | - |
dc.contributor.author | Kim, Boong-Nyun | - |
dc.contributor.author | Hwang, Jun-Won | - |
dc.contributor.author | Shin, Min-Sup | - |
dc.contributor.author | Park, Mira | - |
dc.contributor.author | Cho, Dae-Yeon | - |
dc.contributor.author | Yoo, Hee-Jeong | - |
dc.contributor.author | Chung, Un-Sun | - |
dc.contributor.author | Son, Jung-Woo | - |
dc.contributor.author | Park, Tae-Won | - |
dc.date.accessioned | 2010-04-19 | - |
dc.date.available | 2010-04-19 | - |
dc.date.issued | 2008-10-07 | - |
dc.identifier.citation | Neurosci Lett. 2008 ;446(2-3):108-11. | en |
dc.identifier.issn | 0304-3940 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18835330 | - |
dc.identifier.uri | https://hdl.handle.net/10371/63307 | - |
dc.description.abstract | Findings from preclinical and clinical research support the involvement of central noradrenergic dysregulation in the etiology of attention deficit hyperactivity disorder (ADHD). Previous studies have suggested that the alpha-2C-adrenergic receptor gene (ADRA2C) is associated with ADHD. The aims of this study were to examine the association between the ADRA2C (GT)n repeat polymorphism (STR marker adra2c1) and ADHD in a Korean sample. In this case-control and family-based association study, we assessed 184 ADHD probands, 150 normal controls, and 98 trios. There were no significant differences in the allele frequencies of the ADRA2C polymorphism between the ADHD and control groups (p > 0.05). The overall allele-wise transmission disequilibrium test (TDT) analysis showed statistical significance (chi2 = 19.07, p = 0.025). We found a trend for preferential transmission of the 183-bp allele (chi2 = 3.72, p = 0.054), and a significantly lower-than-expected rate of transmission of the 187-bp allele (chi2 = 6.26, p = 0.012). With regard to the temperament profiles of the Junior Temperament and Character Inventory (JTCI), the ADHD subjects with the 183/183 genotype at the ADRA2C polymorphism showed a trend toward a lower score in the Novelty Seeking (p = 0.020) profile than did those with the other genotypes. Our findings provide important evidence that the ADRA2C polymorphism is involved in the etiology of ADHD in Korean subjects. In addition, our results provide evidence that the temperament of Novelty Seeking and ADHD might share molecular genetic characteristics related to the noradrenergic system. | en |
dc.description.sponsorship | This study is supported in part by the Seoul National University Hospital Research Fund(Grant No. 04-2006-108-0). | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Asian Continental Ancestry Group | en |
dc.subject | Attention Deficit Disorder with | en |
dc.subject | Hyperactivity/ethnology/*genetics/metabolism | en |
dc.subject | Brain Chemistry/*genetics | en |
dc.subject | Child | en |
dc.subject | DNA Mutational Analysis | en |
dc.subject | Exploratory Behavior/physiology | en |
dc.subject | Female | en |
dc.subject | Gene Frequency/genetics | en |
dc.subject | Genetic Markers/genetics | en |
dc.subject | Genetic Predisposition to Disease/*genetics | en |
dc.subject | Genetic Screening | en |
dc.subject | Genotype | en |
dc.subject | Humans | en |
dc.subject | Inheritance Patterns/genetics | en |
dc.subject | Korea | en |
dc.subject | Male | en |
dc.subject | Mutation/genetics | en |
dc.subject | Norepinephrine/*metabolism | en |
dc.subject | Polymorphism, Genetic/*genetics | en |
dc.subject | Receptors, Adrenergic, alpha-2/*genetics | en |
dc.subject | Temperament/physiology | en |
dc.title | Association between the alpha-2C-adrenergic receptor gene and attention deficit hyperactivity disorder in a Korean sample | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 조수철 | - |
dc.contributor.AlternativeAuthor | 김재원 | - |
dc.contributor.AlternativeAuthor | 김붕년 | - |
dc.contributor.AlternativeAuthor | 황준원 | - |
dc.contributor.AlternativeAuthor | 신민섭 | - |
dc.contributor.AlternativeAuthor | 박미라 | - |
dc.contributor.AlternativeAuthor | 조대연 | - |
dc.contributor.AlternativeAuthor | 유희정 | - |
dc.contributor.AlternativeAuthor | 정운선 | - |
dc.contributor.AlternativeAuthor | 손정우 | - |
dc.contributor.AlternativeAuthor | 박태원 | - |
dc.identifier.doi | 10.1016/j.neulet.2008.09.058 | - |
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