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Possible association of the alpha-2A-adrenergic receptor gene with response time variability in attention deficit hyperactivity disorder

Cited 28 time in Web of Science Cited 27 time in Scopus
Authors
Cho, Soo-Churl; Kim, Jae-Won; Kim, Boong-Nyun; Hwang, Jun-Won; Park, Mira; Kim, Soon Ae; Cho, Dae-Yeon; Yoo, Hee-Jeong; Chung, Un-Sun; Son, Jung-Woo; Park, Tae-Won
Issue Date
2008-03-05
Publisher
Wiley-Blackwell
Citation
Am J Med Genet B Neuropsychiatr Genet. 2008 ;147B(6):957-63.
Keywords
Attention Deficit Disorder with Hyperactivity/*genetics/*psychologyCase-Control StudiesChildDeoxyribonuclease HpaII/metabolismDeoxyribonucleases, Type II Site-Specific/metabolismFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansKoreaLinkage DisequilibriumMalePolymorphism, Restriction Fragment LengthReaction Time/*geneticsReceptors, Adrenergic, alpha-2/*genetics
Abstract
Previous studies have demonstrated that the MspI and DraI polymorphisms at the alpha-2A-adrenergic receptor gene (ADRA2A) are associated with ADHD. However, few studies have been designed to ascertain the association between the ADRA2A genotypes and the performance on neurocognitive measures in ADHD. The aims of this study were to examine the association of the ADRA2A MspI and DraI polymorphisms with ADHD in Korean subjects, and to determine the relationship between the genotypes of these two polymorphisms and the candidate endophenotypes, as measured by the continuous performance test (CPT). In a case-control study, we assessed 186 ADHD probands and 150 normal controls. One hundred eight trios were studied in a family based association analysis. The transmission disequilibrium test (TDT) analysis showed preferential transmission of the C allele of the DraI polymorphism (chi(2) = 5.88, P = 0.015). In the haplotype analyses, a trend of over-transmission of haplotype C/C was observed (chi(2) = 3.80, P = 0.051). The homozygous subjects for the C allele (C/C genotype) at the DraI polymorphism showed a trend toward a higher mean T-score with respect to the response time variability profiles of the CPT than did those with the other genotypes (C/T + T/T genotypes; P = 0.042). The homozygous subjects for the G allele (G/G genotype) at the MspI polymorphism showed a tendency to have a lower mean T-score with respect to the response time variability profiles of the CPT (P = 0.068). The results of this study provide important evidence for the involvement of the ADRA2A MspI and DraI polymorphisms in the etiology of ADHD in Korean subjects. In addition, our results provide evidence for the possible role of these two polymorphisms in ADHD symptom expression, such as increased response time variability.
ISSN
1552-485X (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18314873

http://hdl.handle.net/10371/63308
DOI
https://doi.org/10.1002/ajmg.b.30725
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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