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Altered cingulate white matter connectivity in panic disorder patients

Cited 45 time in Web of Science Cited 53 time in Scopus
Authors
Han, Doug Hyun; Renshaw, Perry F.; Dager, Stephen R.; Chung, Ain; Hwang, Jaeuk; Daniels, Melissa A.; Lee, Young Sik; Lyoo, In Kyoon
Issue Date
2007-05-08
Publisher
Elsevier
Citation
J Psychiatr Res. 2008 ;42(5):399-407.
Keywords
AdultAnisotropyBrain Mapping/methodsControl GroupsDiagnostic and Statistical Manual of Mental DisordersDiffusion Magnetic Resonance Imaging/methods/*statistics & numerical dataFemaleFunctional Laterality/*physiologyGyrus Cinguli/metabolism/*physiopathologyHumansImage Processing, Computer-AssistedMaleNeural Pathways/physiopathologyNeuropsychological Tests/statistics & numerical dataPanic Disorder/diagnosis/*physiopathology/psychologyPsychiatric Status Rating Scales/statistics & numerical dataSeverity of Illness IndexTissue DistributionTrail Making Test/statistics & numerical dataWater/metabolism
Abstract
OBJECTIVE: Functional imaging studies of panic disorder subjects suggest an increased activation of the cingulate regions of the brain. Aim of the current study was to explore the white matter connectivity differences between subjects with panic disorder and healthy comparison subjects. METHOD: Structural white matter connectivity, as determined from fractional anisotropy (FA) values obtained by diffusion tensor imaging, was assessed for anterior and posterior cingulate regions in 24 panic disorder patients and 24 age and sex-matched healthy comparison subjects. RESULTS: Subjects with panic disorder exhibited significantly greater FA values in left anterior and right posterior cingulate regions (by 13.3% and 19.6%, respectively) relative to comparison subjects. White matter connectivity for these two cingulate regions was also positively correlated with clinical severity, as determined by Panic Disorder Severity Scale. FA values in left anterior cingulate region negatively correlated with the time of Trail Making Tests and positively with Digit Symbol Substitution Test. CONCLUSIONS: Findings suggest a potential 'enhancement' in white matter connectivity in left anterior and right posterior cingulate regions in panic disorder, and that these changes may play an important role in mediating clinical symptoms of panic disorder.
ISSN
0022-3956 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17482647

http://hdl.handle.net/10371/63312
DOI
https://doi.org/10.1016/j.jpsychires.2007.03.002
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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