인삼 Saponin이 Rat 대뇌피질절편산소 소비량 및 Na+, K+ 소장에 대한 Amphetamine 작용에 미치는 영향
The Effect of Ginseng Saponin on Amphetamine Action of Q02 and Na+, K+ Content in Cerebral Cortex Slices of Rat

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서울대학교 의과대학
Seoul J Med 1971;12(1):24-30
The effect of Ginseng saponin on respiration, Na"
and K+ content of rat cerebral cortex slice was investigated
to determine the action of Ginseng saponin
on brain cortex at cellular level. There are number of
reports on the study of Ginseng concerning central
stimulatory or inhibitory action of it's saponin in experimental
animals. The following results were obtained in this study
concerning the action of Ginseng saponin on the respiration
and Na", K+ concentration in the brain cortex
slices of the rat. It was observed that the respiration
of rat brain slices following Ginseng saponin administration
was decreased.
QO. also reduced by amphetamine alone but Ginseng
saponin stimulated respiration significantly which was
depressed by previous amphetamine administration.
Non-inulin Na tand K+ contents were reduced by
Ginseng saponin together with amphetamine.
There was increase in non-inulin Na" concentration
by Ginseng saponin but no definite changes were
observed in K+ concentration on same subject.
It is suggested that the Ginseng saponin acts rather
on metabolic process than neural excitatory mechanism
in vitro. The possible effects of amphetamine and
Ginseng saponin on the tissue respiration, electrolyte
and QO. of rat brain slices were discussed.
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 12 No.1 (1971)
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