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Long-term efficacy and safety of aripiprazole in patients with schizophrenia, schizophreniform disorder, or schizoaffective disorder: 26-week prospective study
Cited 29 time in
Web of Science
Cited 30 time in Scopus
- Authors
- Issue Date
- 2009-01-22
- Publisher
- Wiley-Blackwell
- Citation
- Psychiatry Clin Neurosci. 2009 ;63(1):73-81.
- Keywords
- Adolescent ; Adult ; Aged ; Antipsychotic Agents/adverse effects/*therapeutic use ; Basal Ganglia Diseases/epidemiology/psychology ; Body Mass Index ; Body Weight/drug effects ; Female ; Humans ; Korea ; Male ; Middle Aged ; Piperazines/adverse effects/*therapeutic use ; Prolactin/blood ; Prospective Studies ; Psychiatric Status Rating Scales ; Psychotic Disorders/*drug therapy/psychology ; Quinolones/adverse effects/*therapeutic use ; Schizophrenia/*drug therapy ; Schizophrenic Psychology ; Suicide/statistics & numerical data ; Young Adult
- Abstract
- AIMS: To date there have been no reports of long-term efficacy of aripiprazole in Asian populations. The aim of the present study was therefore to investigate the long-term efficacy, safety and tolerability of aripiprazole in a large number of patients with schizophrenia, schizophreniform disorder, or schizoaffective disorder in Korea. METHODS: This study was a prospective, multicenter, single-group, 26-week open study of patients with schizophrenia, schizophreniform disorder, or schizoaffective disorder. A total of 300 Korean patients participated in the study. The primary efficacy measure was the Positive and Negative Syndrome Scale (PANSS) total score, and secondary efficacy measures included the PANSS positive and negative subscales, Clinical Global Impression-Severity of Illness (CGI-S). Tolerability and safety were assessed by monitoring the frequency and severity of treatment-emergent adverse events, extrapyramidal symptoms (EPS), vital signs, weight, and laboratory tests. RESULTS: Aripiprazole produced rapid and significant improvements on all efficacy measures. As evidenced by PANSS total score, PANSS positive subscales and the CGI-S scores, first-episode drug-naive patients demonstrated significantly greater efficacy relative to patients who had previously experienced one or more episodes of relapse. Aripiprazole was associated with significant decrease of serum prolactin level. The subjects showed mild weight gain. CONCLUSION: Aripiprazole is an effective antipsychotic in the long-term treatment of both positive and negative symptoms. This study extends the findings of previous long-term studies, and has found that there is no significant difference with regard to ethnicity in response to aripiprazole.
- ISSN
- 1440-1819 (Electronic)
1323-1316 (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19154213
https://hdl.handle.net/10371/63334
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