Exencephalus Found in A Human Embryo

Abstract

An exencephalic embryo was incidentally found in a hysterectomy specimen. It was studied morphologically based on serial sections of the embryo. The embryo was clearly exencephalic showing herniated brain without cranial coverage. Interestingly, remaining brain tissue was morphologically normal although direct continuity of ependyma with skin was identified. These findings are strongly suggestive of the hypothesis that exencephaly is a variant of anencephaly, the only difference being the magnitude of remaining brain tissue in acranic head. There were no associated anomalies in this embryo except for a small intestinal diverticulum. The remainder of the tissue was compatible with Streeter age group XXI.