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Effective Management of Single Dominant Follicle with Continuous Administration of Gonadotropin-Releasing Hormone Agonist

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Authors
Kim, Seok Hyun; Roh, In Hwa; Song, Yong Sang; Kim, Jung Gu; Moon, Shin Yong; Lee, Jin Yong; Chang, Yoon Seok
Issue Date
1992-03
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med, Vol.33 No.1, pp. 51-55
Keywords
IV FCOHGnRH-αPoor respondersSingle dominant follicle
Abstract
With the widespread use of gonadotropin-releasing hormone agonist
(GnRH-a) for in vitro fertilization(IVF) program, the cancellation rate during controlled
ovarian hyperstimulation(COH} is much lowered. However, poor responders with poor
estradioI(E2} rise or single dominant follicle still persist in GnRH-a combined COH,
and the decision to cancel the cycle and the counselling of further cycles remain very
perplexing. Three poor responders with single dominant follicle during GnRH-a
combined COH for IVF were, rather than being cancelled, managed by continuous
administration of GnRH-a and restimulation with initial low dosage and subsequent
high dosage of follicle-stimulating hormone until an appropriate number of follicles was
obtained. While no pregnant case treated in this way, the management resulted in a
higher E2 level, and more oocytes and embryos. We suggest that this approach could
serve as an alternative to cancellation in GnRH-a combined COHo
ISSN
0582-6802
Language
English
URI
http://hdl.handle.net/10371/6341
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 33 No.1 (1992)
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