Publications
Detailed Information
Impact of coexistent schizotypal personality traits on frontal lobe function in obsessive-compulsive disorder
Cited 14 time in
Web of Science
Cited 13 time in Scopus
- Authors
- Issue Date
- 2007-11-03
- Publisher
- Elsevier
- Citation
- Prog Neuropsychopharmacol Biol Psychiatry. 2008 ;32(2):472-8.
- Keywords
- Adult ; Age Factors ; Comorbidity ; Control Groups ; Educational Status ; Female ; Frontal Lobe/*physiopathology ; Humans ; Male ; Neuropsychological Tests/*statistics & numerical data ; Obsessive-Compulsive Disorder/diagnosis/*epidemiology/*physiopathology ; Schizotypal Personality Disorder/diagnosis/*epidemiology/*physiopathology ; Sex Factors ; Speech Disorders/diagnosis/epidemiology
- Abstract
- OBJECTIVE: This study was a post-hoc analysis of the results from a neuropsychological battery which was conducted to investigate the frontal lobe difference between obsessive-compulsive disorder (OCD) patients with and without schizotypal personality trait (SPT), especially dorsolateral prefrontal and medial frontal functions. METHODS: Fifty-five OCD patients were divided into two groups according to their Personality Disorder Questionnaire-4+ scores. Patients with OCD with SPT (n=17) and OCD without SPT (n=38) were compared to 52 schizophrenia patients and 67 healthy subjects. Two neuropsychological tasks, the Wisconsin Card Sorting Test (WCST) and verbal fluency tests which are considered to reflect dorsolateral and medial frontal functions, were selected for an analysis. RESULTS: OCD with SPT patients and patients with schizophrenia performed significantly worse than controls in both the WCST and verbal fluency tasks, whereas OCD without SPT patients showed no deficits in the same tasks. Moreover, we found no statistically significant difference in either task between patients having OCD with SPT and patients with schizophrenia. CONCLUSION: This study indicate that OCD with SPT may have distinct patterns of neurocognitive deficit that differ from those of OCD without SPT, especially in terms of frontal lobe function.
- ISSN
- 0278-5846 (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17976879
https://hdl.handle.net/10371/63546
- Files in This Item:
- There are no files associated with this item.
- Appears in Collections:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.