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Impact of coexistent schizotypal personality traits on frontal lobe function in obsessive-compulsive disorder

Cited 13 time in Web of Science Cited 12 time in Scopus
Authors
Shin, Na Young; Lee, Ae Ra; Park, Hye Yoon; Yoo, So Young; Kang, Do-Hyung; Shin, Min Sup; Kwon, Jun Soo
Issue Date
2007-11-03
Publisher
Elsevier
Citation
Prog Neuropsychopharmacol Biol Psychiatry. 2008 ;32(2):472-8.
Keywords
AdultAge FactorsComorbidityControl GroupsEducational StatusFemaleFrontal Lobe/*physiopathologyHumansMaleNeuropsychological Tests/*statistics & numerical dataObsessive-Compulsive Disorder/diagnosis/*epidemiology/*physiopathologySchizotypal Personality Disorder/diagnosis/*epidemiology/*physiopathologySex FactorsSpeech Disorders/diagnosis/epidemiology
Abstract
OBJECTIVE: This study was a post-hoc analysis of the results from a neuropsychological battery which was conducted to investigate the frontal lobe difference between obsessive-compulsive disorder (OCD) patients with and without schizotypal personality trait (SPT), especially dorsolateral prefrontal and medial frontal functions. METHODS: Fifty-five OCD patients were divided into two groups according to their Personality Disorder Questionnaire-4+ scores. Patients with OCD with SPT (n=17) and OCD without SPT (n=38) were compared to 52 schizophrenia patients and 67 healthy subjects. Two neuropsychological tasks, the Wisconsin Card Sorting Test (WCST) and verbal fluency tests which are considered to reflect dorsolateral and medial frontal functions, were selected for an analysis. RESULTS: OCD with SPT patients and patients with schizophrenia performed significantly worse than controls in both the WCST and verbal fluency tasks, whereas OCD without SPT patients showed no deficits in the same tasks. Moreover, we found no statistically significant difference in either task between patients having OCD with SPT and patients with schizophrenia. CONCLUSION: This study indicate that OCD with SPT may have distinct patterns of neurocognitive deficit that differ from those of OCD without SPT, especially in terms of frontal lobe function.
ISSN
0278-5846 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17976879

http://hdl.handle.net/10371/63546
DOI
https://doi.org/10.1016/j.pnpbp.2007.09.020
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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